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C. ALLEN CHANG, Ph.D. ±i ¥¿

National Chiao Tung University, Hsinchu, Taiwan
Department and Institute of Biological Science and Technology.
TEL: (03) 5712121 ext. 56903; FAX: (03) 5729288
E-Mail: changca@cc.nctu.edu.tw

EXPERIENCE:

1994 NATIONAL CHIAO TUNG UNIVERSITY, Hsinchu, Taiwan
- Present Outstanding Chair Professor and Founder (Director), Department and Institute of Biological Science and Technology. R&D in the areas of biopharmaceutical, bioanalytical, bioinorganic and lanthanide coordination chemistry. Teaching (Graduate courses: Introduction to Biological Sciences and Technology - Academic and Industrial Perspectives; Advanced Bioanalytical Chemistry; Undergraduate course: Bioanalytical Chemistry); Research (New Magnetic Resonance Imaging Contrast Media; Coordination Chemistry of Macrocyclic Lanthanide Complexes and Biomedical Applications; New Biopharmaceutical Substances and Formulations; Herbal Medicine and Health Food Development, Anti-Aging Nutrient Suppliment; HPLC and CE Studies of Biomolecules; Novel Immunodiagnostic and Therapeutic Agents and Devices); Administration (Strategic planning, policy setting, committee meetings, daily operations, personnel management, and recruiting.) Planned the Institute of Biomedical Engineering and the College of Biological Science and Technology.

Coordinator, Biotechnology Incubation Center. Management, Strategic Planning, R&D, Marketing Consulting. Served as consultant for two companies: United Biotech Corporation and PhytoHealth Corporation.

1992-94 Grace Pharmaceutical & Technology Co., Palo Alto, CA.
Principal. Pharmaceutical, biotechnology, and chemical consultation and new business development. In vivo diagnostic and therapeutic drug discovery research and development. Bioanalytical methods development and medical device R&D. Companies served included Glaxo, Abbott, West, Metasyn, G.D. Searle, etc.

Nang Kuang Pharmaceutical Co., Tainan, Taiwan. (1993-1994)
Executive Consultant and Director, R&D. New business development, international and domestic market awareness, long and short term R&D planning and execution.

Frost & Sullivan Market Intelligence, Mountain View, CA. (1992-1993)
Director of Market Research. Directed primary market research in pharmaceutical, biotechnology, medical imaging, and analytical instrumentation industry areas.

1990-92 Nycomed Salutar, A Hafslund Nycomed Co. (Oslo, Norway), Sunnyvale, CA.
Vice President, Research. Directed activities of entire scientific group in the research and development of Salutar products, projects and programs in the in vivo diagnostic pharmaceutical areas, including all drug discovery, IND and NDA activities. Led a group of more than 30 professionals and managed an annual budget of more than 3 million U.S. dollars.

Director, Analytical Sciences. Directed the analytical and physical chemistry research, the development, implementation and maintenance of chemical and bioanalytical methods and validation studies, quality control, release and stability testing, and documentation.

1987-90 Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ.
Group Leader, Contrast Media Research, Diagnostics Division.
Lead a group of 4 Ph.D. and 3 M.S./B.S. professionals. Bioinorganic and analytical chemistry: lanthanide coordination chemistry, macrocyclic chemistry and chromatography. R&D of new contrast agent for magnetic resonance imaging and radiography. Labeled monoclonal antibody therapeutic agents. Design, synthesis, and purification of new chemical entities. Drug safety studies. Efficacy and dosage design. Documentation, legal, and marketing support.

¡¯ Nuclear magnetic resonance imaging (NMRI) studies.
¡¯ Nuclear magnetic resonance relaxivity/dispersion (NMRD) studies.
¡¯ Proton relaxation enhancement.
 ® ¡¯ Ligand design and metal chelate synthesis.
¡¯ Separation and purification method development.
¡¯ Analytical method development and trace analysis.
¡¯ Drug stability and potency tests.
¡¯ Drug formulation research and stress tests.
¡¯ Metal and ligand speciation studies.
¡¯ Thermodynamic and kinetic studies of metal complex formation and dissociation reactions.
¡¯ Crystal and solution structural characterizations.
 ® ¡¯ Study of intermolecular interactions, osmometry, viscometry and calorimetry.
¡¯ Radiochemistry, labeling and radiation effects.
¡¯ Study of drug partition, log P measurements.
¡¯ Bioconjugate chemistry.
¡¯ Assistance in IND and NDA and patent applications.

 P Project team member to study biodistribution, pharmacology, toxicology, and pathology.
Coordinator of division seminar program.
 C Chairman of Contrast Media Working Group Meeting.
Participation in Radiopharmaceutical Macromolecular Labeling and Diagnostic Pharmaceutical Implementation Working Group Meetings.
ProHanceR Advisory Committee member.

1986-87 Aluminum Company of America, Pittsburgh, PA
Group Leader, Chromatography and Bioseparations, Separations Technology Division. Responsible for the establishment of the Chromatography Group.

Research and Development:
¡¯ Develop novel alumina and silica based reversed-phase packings, ion exchangers, and chiral bonded phases for liquid chromatography.
¡¯ Develop novel packed and capillary gas and supercritical fluid chromatographic columns.
¡¯ Column packing technology and tests.
¡¯ Analytical application of column products.
¡¯ Develop immobilized chelate adsorbents.
¡¯ Bioseparations and biotechnology.

Marketing and Sales Planning:
¡¯ Assessment of market needs.
¡¯ Making industrial and university contacts.
¡¯ Making technical recommendations concerning strategic planning.

University of Texas at El Paso, El Paso, TX
1985-88 Associate Professor of Analytical Chemistry (tenured)
1980-85 Assistant Professor of Analytical Chemistry
Teaching graduate and undergraduate analytical, inorganic, and general chemistry courses. Lead a research group of 5 postdoctoral fellows and 8 graduate and undergraduate students.

Research activities:
¡¯ HPLC with chiral and metal complex and cyclodextrin bonded phases.
¡¯ Separation of enantiomers. Separation mechanisms of polar bonded phases.
¡¯ Biomedical and pharmaceutical analysis. LCEC for trace analysis.
¡¯ Design, synthesis, and characterization of metal ion selective reagents.
¡¯ Thermodynamics and kinetics of metal complexation reactions and solvent extractions.
¡¯ Interfacial electrochemistry.

1979-80 University of Maine, Orono, ME
Research Associate, Department of Chemistry.
Co-investigator, study of geochemical cycling and speciation of chromium in aquatic and marine environment. Photoluminescence and chemiluminescence analysis of trace heavy metals. Study of heavy metal catalysis of chemiluminescence reactions. Synthesis and characterization of mixed valence platinum blue antitumor drugs.

1978-79 Wellesley College, Wellesley, MA
Assistant Professor of Chemistry.
Teaching inorganic and general chemistry courses; coordinator of general and inorganic chemistry laboratory experiments.

1978-79 Massachusetts Institute of Technology, Cambridge, MA
Visiting Scientist, Department of Chemistry.
Photocatalysis of hydrosilation of olefins. ?EDUCATION

Ph.D. University of Pittsburgh, Inorganic-Analytical Chemistry, 1978. GPA 4.00/4.00
B.S. National Taiwan University, Physical-Analytical Chemistry, 1974.

HONORS AND PROFESSIONAL ACHIEVEMENTS

97+ Refereed articles in primary journals.
90+ Abstracts in scientific meetings.
60 Industrial research reports.
110+ Invited seminars.
25 Management and technical courses.
5 Patent applications/disclosures.

Co-founder, National Chiao Tung University Biotechnology Incubation Center (1997).

Member, Metallobiochemistry Study Section, Division of Research Grants, National Institute of Health, U.S. (July, 1990 - June, 1994); Principal reviewer of most pharmaceutical, biotechnology, bioinorganic chemistry, bioanalytical chemistry, and chromatography proposals. Reviewers Reserve (1994-1998)

Editorial Advisory Board, Bioconjugate Chemistry (1992-97)

Editorial Board, Instrument Today ¬ì»ö·sª¾ (1997- present).

Member, Technology Financial Support Program Evaluation Committee, Ministry of Economics, R.O.C.¸gÀÙ³¡¬ì§Þ±M®×ÁZ®Ä¦Òµû©e­û·|©e­û (1999-present)

Member, Biotechnology & Pharmaceutical Industry Program Committee, Ministry of Economic Affairs, R.O.C. (1997-present)

Member, Program Evaluation Committee, Department of Industrial Technology, Ministry of Economic Affairs, R.O.C. (2000-present)

Member, Consulting Committee, Department of Research Resourses, National Health Research Institute, R.O.C. (2000-2002)

Consultant, National Science Council, Science Park Administration (1995-present)

Member, 4th Labor Training Program Committee, Council of Labor Affairs, R.O.C. (1997)

Consultant, Union Chemical Laboratories (1997-1998)

Member, National Chiao Tung University Executive MBA Program Committee ¥æ³q¤j¾Ç°ª¶¥¥øºÞ¯Z¾Çµ{©e­û (1998-present).

Member, National Chiao Tung University Technology Licensing Office ¥æ³q¤j¾Ç´¼¼z°]²£Åv¤¤¤ßµû¶q©e­û»P§Þ³NÅU°Ý (2001-present).

Consultant, United Biotech Corp., PhytoHealth Corp., Allied Industrial Corp., Longevity Institute Taiwan (1997-present), BioMed. Global, Inc. (2001-present).

Reviewer of technical proposals (DOE, NIH, ACS, and NSC), scientific papers and books (J.Am. Chem. Soc., Bioconjugate Chem., Inorg. Chem., J. Chromatogr., Pharma. Res., J. Coord. Chem., Nucl. Med. Biol., J. Chem. Ed., Trans. Metal. Chem., J. Chin. Chem. Soc.)

More than 1.5 million US dollars external research grants at UTEP - DOE, NIH, ACS, Research Corporation, Welch Foundation, State of Texas, Meadow's Foundation (1980-1988). More than 13 million NT external research grant in Taiwan (1994-2000).

Top-rated in teaching, research, and service at UTEP. Supervised 7 post-doctoral fellows, 13 graduate students, and 20 undergraduate and high school (ACS Project SEED) students.

Members of American Chemical Society, Society of Magnetic Resonance in Medicine, American Association of Pharmaceutical Scientists, Sigma Xi, American Association for the Advancement of Science, New York Academy of Sciences. Chinese Chemical Society, ACS Rio Grande Valley Section, chairman-elect (1986), secretary/treasure (1983) analytical chemistry program chairman (1982).

Presider/discussion leader of international and national technical meetings (Pittsburgh Conference, International Symposium on Macrocyclic Chemistry, ACS).

Consultant, Abbott Laboratories, Glaxo, G.D. Searle, Metasyn, Ballard Research, Inc. and General Electric Co.

Co-developer of three magnetic resonance imaging contrast agents, ProHance (Squibb Diagnostics) and Omniscan and Teslascan (Nycomed Imaging), currently marketed worldwide.

Founded the first academic biological science and technology institute in Taiwan emphasizing integrated R&D and industrial applications.

National Science Council Research Award, Taiwan, R.O.C. (1994).

Foundation for the Advancement of Outstanding Scholarship Award, Taiwan, R.O.C. (1995-2000).

SUMMARY OF RESEARCH ACCOMPLISHMENTS

I was originally trained as an inorganic and analytical chemist with research interests in biological applications. My undergraduate research (1974) work was on the study of uranyl complex formation with £]-isopropyltropolone (J. Chinese Chem. Soc., 1977, 24, 11-19). My Ph.D. thesis work was on the study of the stability, structure, and stereochemistry (including optical activity) of metal complexes using carbon-13 NMR, circular dichroism, optical spectroscopy, and potentiometric techniques (1974-78, total 6 publications, example: Inorg. Chem., 1979, 18, 1266-1271). My postdoctoral research was primarily on bioinorganic and environmental analytical chemistry, i.e. platinum anti-tumor drug characterizations and estuary chromium speciation (1979-80, total 6 publications, examples: Anal. Chem.,1980, 52, 653-656; Inorg. Chem., 1981, 20, 1632-1636).

At the University of Texas at El Paso (UTEP, 1980-1988), I worked on two major research projects: liquid chromatography and macrocyclic lanthanide coordination chemistry. Both projects were well funded by a number of agencies including ACS-PRF, National Institutes of Health, Department of Energy, Research Corporation, the State of Texas and the Robert A. Welch Foundation (total amount exceeded 1.5 million U.S. dollars). I was granted tenure with promotion to Associate Professor of Chemistry at UTEP in 1985.

In liquid chromatography, I initiated the use of substitution-inert metal complex bonded and mobile phases to achieve unique separation selectivity and low detection limits (total 12 publications, examples: Anal. Chem., 1982, 54, 1179-1182; ibid, 1983, 55, 1390-1395; ibid, 1985, 57, 997-1005; J. Chromatogr., 1984, 312, 99-107; ibid, 1987, 404, 282-284). Later I was concentrating on the liquid chromatographic separation mechanisms, particularly those of cyclodextran bonded phases. I was the first to show that the separation mechanisms were different for the cyclodextran bonded phases in the normal and reversed phase separation modes (total 10 publications, examples: J. Chromatogr., 1985, 347, 51-60; ibid, 1986, 371, 269-282; ibid, 1990, 522, 143-152; J. Phy. Chem., 1987, 91, 1953-1956; ibid, 1988, 92, 1682-1685). During 1986-87, I took a leave of absence from the UTEP to join Aluminum Co. of America where I developed the prototype of polymer-coated platelet alumina for liquid chromatography at normal and extreme pH conditions (this product is now marketed by Biotage). In addition to liquid chromatography, I also made contributions in the areas of gas chromatography, interfacial electro-analytical chemistry, and bioanalytical chemistry (more than 8 publications).

I was one of the pioneers in the study of macrocyclic lanthanide coordination chemistry and biomedical applications. The initial idea was to make lanthanide ion selective reagents for both medical and separation applications. A comprehensive and systematic study approach was undertaken. This included the design and synthesis of macrocyclic ligands and their lanthanide complexes, thermodynamic and kinetic studies of metal complex stability, selectivity, and lability, solution and solid state structural characterizations, and solvent extraction applications. More than 20 research articles have been published (examples: Inorg. Chem., 1983, 22, 3866-3869; ibid, 1986, 25, 355-358; ibid, 1986, 25, 2061-2065; ibid, 1987, 26, 1981-1985; ibid, 1990, 29, 2651-2658; ibid, 1991, 30, 3270-3275; Anal. Chem., 1986, 58, 2269-2275; ibid, 1987, 59, 813-818; Inorg. Chim. Acta, 1987, 130, 117-118; J. Org. Chem., 1988, 53, 5-9; Solvent Extr. Ion Exch., 1989, 7, 413-433). Among the major discoveries were (1) many macrocyclic ligands that exerted unprecedented selectivities toward lanthanide ion binding, (2) the dissociation of macrocyclic lanthanide complexes was not catalyzed by other metal ions (this has very important implications in the design of lanthanide magnetic resonance imaging contrast agents, vide infra), (3) the kinetic control of solvent extraction selectivity of lanthanides, and (4) the expanded study of lanthanide solution structural properties using a novel laser fluorescence technique.

In 1987, Squibb Institute for Medical Research invited me to join them to develop novel and practical (i.e. safe and efficacious) lanthanide magnetic resonance imaging (MRI) contrast agents. Upon my arrival, I quickly established a new physical and analytical chemistry group and solved all the major problems that had eluded the Contrast Media Research Department for several years. I have played a major role in the R&D history of MRI contrast agents and continued to publish new findings and gave international invited talks. I have published more than 15 papers since 1990 in this field (for details see publications below).

I have co-developed three MRI contrast agents, Squibb's ProHanceR and Nycomed's OmniscanR and TeslascanR, all are lanthanide/transition metal coordination compounds. In 2000, the combined worldwide sales of these three agents are expected to exceed 100 million USD. The MRI contrast agent drug discovery and development processes are not simple and require an interdisciplinary approach. It is quite costly and time-consuming and only those organizations with good management and a mastery of sound scientific and business decisions and executionscan thrive through rigorous competition.

I have published approximately 180 scientific papers and abstracts, and numerous research reports and patents. In industry, I have experience in managing more than 30 professionals with an annual budget of more than 3 million U.S. Dollars. In academic institutions, I have trained more than 50 postdoctoral fellows and graduate students. I have been invited to give seminars and oral presentations at many universities (e.g. Pennsylvania State University, U.S.A. and University of Laussane, Switzerland), industrial companies (e.g. G.D. Searle, Syntex and Exxon), and technical conferences (e.g. American Chemical Society, Society of Magnetic Resonance in Medicine and Pittsburgh Conference). I was a member of the Metallobiochemistry Study Section of the National Institutes of Health (1990-1994) and Reviewers Reserve (1994-1998). I was also a member of the Editorial Advisory Board of Bioconjugate Chemistry (1992-1997).

From 1992-1994, I founded Grace Pharmaceutical and Technology Company and worked as a consultant for a number of pharmaceutical companies. I was also appointed as Director of Market Research, Frost and Sullivan Market Intelligence Company, working in the pharmaceutical and biotechnology fields. I have directed more than six major market research reports in the areas of neurological pharmaceuticals, in vitro diagnostics, drug packaging, and bioanalytical instrumentation.

From 1994 to 1999, I have been appointed as Professor and Director of the Department and Institute of the Biological Science and Technology at National Chiao Tung University (I was the founder of the department and institute). This department is the first of its kind because I emphasize on both fundamental and applied teaching and reseach so that our students are trained with innovative thinking and creative problem solving. It is ranked within the top five bioscience related departments according to the national entrance examination score in 1999 and 2000. My current R&D interests are in the areas of biopharmaceutical chemistry (i.e. new generation MRI contrast agents, Chinese medicines, placental growth factors, anti-aging formulations, anti-sense drug design and characterizations, and immunodiagnostics), bioinorganic chemistry (i.e. lanthanide and transition metal coordination biochemistry, i.e. artificial ribonucleases), and bioanalytical chemistry (i.e. HPLC and CE of biomolecules, biosensors).

PUBLICATIONS

A. Refereed Papers

1. T.M. Hseu, C.A. Chang and K.L. Hsu. "Spectrophotometric studies of Uranyl (VI) Chelate of £]-Isopropyltropolone", J. Chin. Chem. Soc. (Taipei), 1977, 24, 11-19.

2. G.G. Hawn, C.A. Chang and B.E. Douglas. "Circular Dichroism and Carbon-13 Nuclear Magnetic Resonance Studies of Some Phenyl Substituted Ethylenediamine-N,N,N',N'-tetraacetate Analogs", Inorg. Chem., 1979, 18, 1266-1271.

3. C.A. Chang and B.E. Douglas. "Stereochemical Studies of Cobalt(III) Complexes of Sexi-dentate Aminopolyacids Using Carbon-13 Chemical Shifts", J. Coord. Chem., 1979, 9, 93-106.

4. D.E. Bause, C.A. Chang and B.E. Douglas. "Carbon-13 Nuclear Magnetic Resonance Studies of Cobalt(III) Complexes of Ethylenediamine-N,N,N'-triacetate Type Ligands", J. Coord. Chem., 1979, 9, 211-219.

5. C.A. Chang and B.E. Douglas. "Carbon-13 Nuclear Magnetic Resonance Study of Polar -(nitro)-trimethylenediamine-N,N,N'-triacetatocobaltate (III) Ion", J. Coord. Chem., 1980, 10, 131-134.

6. C.A. Chang and H.H. Patterson. "Halide Ion Enhancement of Chromium(III) , Iron(II), and Cobalt(II) catalysis of Luminol Chemiluminescence", Anal. Chem., 1980, 52, 653-656.

7. C.A. Chang, H.H. Patterson, L.M. Mayer, and D.E. Bause. "Determination of Trivalent Chromium in Sea Water by Chemiluminescence", Anal. Chem., 1980, 52, 1264-1267.

8. C.A. Chang, R.B. Marcotte, and H.H. Patterson. "The Platinum Phthalimide Blues: Synthesis and Physical Characterization. Hush Model Interpretation of optical Spectra", Inorg. Chem., 1981, 20, 1632-1636.

9. C.A. Chang and B.E. Douglas. "Stabilities of Complex Formation Between Triethylene-teraamine-N2,N3-Diacetic Acid and Some Transition Metal Ions", J. Coord. Chem., 1981, 11, 91-97.

10. C.A. Chang and C.F. Tu. "High Performance Liquid Chromatographic Selectivities of Dihydroxybenzenes Using Silica, Diamine, and Cobalt Complex Bonded Phase Columns", Anal. Chem., 1982, 54, 1179-1182.

11. C.A. Chang. "Thermodynamic Parameters of Liquid Chromatographic separations of Fructose, Glucose, and Sucrose with Amine and Cobalt Complex Bonded Phases", Anal. Chem., 1983, 55, 971-974.

12. C.A. Chang, C.S. Huang, and C.F. Tu. "Characterization of Substitution-Inert Cobalt(III) Complex Bonded Phases in Liquid Chromatography", Anal. Chem., 1983, 55, 1390-1395.

13. L.M. Mayer, L. Shick, and C.A. Chang. "Kinetics of Trivalent Chromium Complexation and Adsorption at the River-Estuary Interfaces: Implications for Reactive Pollutant Transport", Heavy Met. Environ., Int. Conf., 4th, 1983, 2, 1112-1115.

14. C.A. Chang and M.E. Rowland. "Metal Complex Formation with 1,10-Diaza-4,7,13,16-Tetraoxacyclooctadecane-N,N'-Diacetic Acid, An Approach to Potential Lanthanide Ion Selective Reagents", Inorg. Chem., 1983,22, 3866-3869.

15. D.V. Marquez, R. Aguilar, and C.A. Chang. "An Automated Reagent Addition System with an Infrared Drop Detector", J. Chinese Chem. Soc. 1984, 31, 205-209.

16. C.A. Chang, E.N. Duesler, and R.E. Tapscott. "The Crystal and Molecular Structure of 1,9-Diamino-4-Methyl-3,7-Diazanonane-3,7-Diacetatocobalt(III) Nitrate Monohydrate - A Complex Exhibiting Large 13C NMR Steric Shift", Inorg. Chem. Acta, 1984, 85, 73-78.

17. C.A. Chang, C.F. Tu, and C.S. Huang. "Normal Phase Separation of Chloroanilines and Nitroanilines with Silica, Amine, and Cobalt(III) Complex Bonded Phases", J. Chromatogr. Sci., 1984, 22, 321-326.

18. C.A. Chang, C.S. Huang, and J.M. Hoffer. "Determination of Silica Surface-Confined Cobalt by Energy Dispersive X-Ray Fluorescence Spectrometry", Analyst, 1984, 109, 99-100.

19. L.M. Mayer, L.L. Schick, and C.A. Chang. "Incorporation of Trivalent Chromium into Riverine and Estuarine Colloidal Material", Geochimica et Cosmochimica Acta, 1984, 48, 1717-1722.

20. C.A. Chang and K.L. Fong. "Substitution-Inert Metal Complex Mobile Phases in Non-Suppressed Anion Chromatography", J. Chromatogr., 1984, 312, 99-107.

21. C.A. Chang and C.S. Huang. "Effect of Solvent Composition and Temperature on the Separation of Anilines with Silica, Amine, and Diamine Bonded Phase Columns", Anal. Chem., 1985, 57, 997-1005.

22. C.A. Chang and L.D. Tan. "Effects of Solvent Composition and Temperature on the Normal Phase Liquid Chromatographic Separation of Phenols", J. Liq. Chromatogr., 1985, 8, 995-1007.

23. C.A. Chang, C.S. Huang, and P.D. Murphy. "Synthesis and Spectroscopic Characterization of Substitution-Inert Cobalt(III) Complex Bonded Silicas", Inorg. Chem., 1985, 24, 4216-4218.

24. C.A. Chang, H. Abdel-Aziz, N. Melchor, Q. Wu, K.H. Pannell, and D.W. Armstrong. "Liquid Chromatographic Retention Behavior of Organometallic Compounds and Ligands with Amine, Octadecylsilica, and £]-Cyclodextrin Bonded Phase Columns", J. Chromatogr., 1985, 347, 51-60.

25. C.A. Chang. V.O. Ochaya, and V.C. Sekhar. "Unusual Thermodynamic and Kinetic Properties of Lanthanide Complexes of 1,7-Diaza-4,10,13-Trioxacyclopentadecane-N,N'-Diacetic Acid", J. C. S. Chem. Commun., 1985, 1724-1725.

26. C.A. Chang. J. Twu, and R.A. Bartsch. "pH-Dependent Metal Selectivity by a Crown Ether Carboxylic Acid", Inorg. Chem., 1986, 25, 396-398.

27. C.A. Chang and V.O. Ochaya. "Potential Lanthanide Ion Selective Reagents III. Metal Complex Formation with 1,7-Diaza-4,10,13-Trioxacyclopentadecane-N,N'-Diacetic Acid", Inorg. Chem, 1986, 25, 355-358.

28. C.A. Chang, B.S. Garg, V.K. Manchanda, V.O. Ochaya, and V.C. Sekhar. "Mixed Ligand Complexes of Lanthanides with Macrocyclic and Open-chained Aminopolyacids and Acetylacetone", Inorg. Chim. Acta, 1986, 115, 101-106.

29. C.A. Chang, Q. Wu, and D.W. Armstrong. "Reversed Phase HPLC Separation of Substituted Phenolic Compounds with a £]-Cyclodextrin Bonded Phase Column", J. Chromatogr., 1986, 354, 454-458.

30. V.C. Sekhar and C.A. Chang. "Dissociation Kinetics of 1,7-Diaza-4,10,13-Trioxacyclopenta-decane-N,N'-Diacetic Acid Complexes of Lanthanides", Inorg. Chem., 1986, 25, 2061-2065..

31. C.A. Chang, Q. Wu, and L. Tan. "Normal Phase HPLC Separations of Positional Isomers of Substituted Benzoic Acids with Amine and £]-Cyclodextrin Bonded Phase Columns", J. Chromatogr., 1986, 361, 199-207.

32. V.K. Manchanda and C.A. Chang. "Solvent Extractions of Lanthanum(III) and Neodymium(III) with Ionizable Macrocyclic Ligands and Thenoyltrifluoroacetone", Anal. Chem., 1986, 58, 2269-2275.

33. C.A. Chang and Q. Wu. "Comparison of Liquid Chromatographic Separations of Geometrical Isomers of Substituted Phenols with £]- and £^-Cyclodextrin Bonded Phase Columns", Anal. Chim. Acta, 1986, 189, 293-299.

34. M.P. Eastman, B. Freiha, B. Kessel, and C.A. Chang. "Magnetohydrodynamics of Nematic Mesophases by ESR", Liquid Crystals, 1986, 1, 147-153.

35. C.A. Chang, Q. Wu, and M.P. Eastman. "Effects of Mobile Phases on the Separation of Substituted Anilines with a Cyclodextrin Bonded Phase Column", J. Chromatogr., 1986, 371, 269-282.

36. C.A. Chang, V.C. Sekhar, B.S. Garg, F.S. Guziec, Jr., and T.C. Russo. "Equilibria and Kinetics of Some Metal Complexes of Peptide Hydroxamic Acids", Inorg. Chim. Acta, 1987, 135, 11-18.

37. M.P. Eastman, B. Freiha, C.C. Hsu, K.C. Lum, and C.A. Chang. "Weak Complexation of Nitroxide Radicals by Cyclodextrins", J. Phys. Chem., 1987, 91, 1953-1956.

38. C.A. Chang and Q. Wu. "Facile Liquid Chromatographic Separation of Geometrical Isomers with £^-Cyclodextrin Bonded Phase Column", J. Liq. Chromatogr., 1987, 59, 1359-1368.

39. V.K. Manchanda and C.A. Chang. "Solvent Extraction Studies of Europium(III), Ytterbium(III), and Lutetium(III) with Ionizable Macrocyclic Ligands and Thenoyltrifluoroacetone", Anal. Chem., 1987, 59, 813-818.

40. C.A. Chang and V.C. Sekhar. "Dissociation Kinetics of 1,10-Diaza-4,7,13,16- Tetraoxacyclooctadecane-N,N'-Diacetic Acid Complexes of Lanthanides", Inorg. Chem., 1987, 26, 1981-19685.

41. C.A. Chang, H. Ji, Q. Wu, M.P. Eastman, and S.T.J. Lai. "Use of Cyclodextrin Bonded Columns for the Liquid Chromatographic Separation of Styrene Polymers", Anal. Chim. Acta, 1987, 194, 287-292.

42. Z. Pang, C.A. Chang, and E. Wang. "The Study on the Transfer of the Basic Electrolyte Ion TBA+ Across the Water/Nitrobenzene Interface by Linear Current-Scanning Method", J. Electroanal. Chem., 1987, 234, 71-84.

43. V.C. Sekhar, C.A. Chang, and S. Sherman. "Kinetics of Acid-Catalyzed Dissociation of Lead(II) and Copper(II) Complexes of Ethylenebis(Oxyethylene-nitrilo)tetraacetic Acid (EGTA)", Inorg. Chim. Acta, 1987, 130, 157-162.

44. C.A. Chang, V.K. Manchanda, and J. Peng. "Macrocyclic Reagents for the kinetic Control of Chelate Extraction Selectivities of Lanthanides ", Inorg. Chim. Acta, 1987, 130, 117-118.

45. C.A. Chang, Q. Wu, and C. Sheu. "Determination of Parts-per-Billion Level Cations with Non-suppressed Ion Chromatography and Indirect Photometric Detection", J. Chromatogr., 1987, 404, 282-284.

46. G. Lin and C.A. Chang. "A new heavy Alkylated Benzene Stationary Phase for the Gas-Liquid chromatographic Separation of C1-C6 Light Hydrocarbons", J. Chromatogr., 1987, 404, 328-332.

47. G. Lin and C.A. Chang. "A new Heavy Alkylated Benzene Stationary Phase for the Gas-Liquid Chromatographic Separation of Ethylbenzene, Xylenes, Styrene, Iso- and n-propylbenzene", J. Chromatogr., 1987, 409, 371-376.

48. Z. Pang, C.A. Chang, and E. Wang. "The Compensation for Ohm Drop in the Measurement of Potential Difference at ITIES", J. Electroanal. Chem., 1988, 243, 81-86.

49. C.A. Chang, P.H.L. Chang, and S. Qin. "Decreased Overall Basicity of a Series of New N,N'-Dicarboxymethyl Macrocyclic Ether-Bislactones Derived from EDTA and the Ring Size Effect on the Stability Constants of Their Lanthanide Complexes", Inorg. Chem., 1988, 27, 944-946.

50. A. Czech, B.P. Czech, R.A. Bartsch, C.A. Chang, and V.O. Ochaya. "Synthesis and Complexing Properties of Diazacrown and Cryptand Ligands with Inward-Facing Phenolic Groups", J. Org. Chem., 1988, 53, 5-9.

51. M.P. Eastman, B. Freiha, C.C. Hsu, and C.A. Chang. "Complexation of Nitroxide Radicals by £^-Cyclodextrin", J. Phys. Chem., 1988, 92, 1682-1685.

52. Z. Pang, E. Wang, and C.A. Chang. "Study on the Transfer of the Basic Electrolyte Ion TPAs+ Across the Water/Nitrobenzene Interface by Linear Current-Scanning Method", Electrochimica Acta, 1988, 33, 1291-1293.

53. C.A. Chang, T.E. Woodhouse, Q. Wu, C. Sheu, and K. McManus. "Substitution-Inert Metal Complex Mobile Phases In Non-Suppressed Cation Chromatography", J. Chinese Chem. Soc., 1988, 35, 253-260.

54. C.A. Chang, P.H.L. Chang, V.K. Manchanda, and S.P. Kasprzyk. "Equilibria and Dissociation Kinetics of Lanthanide Complexes of Some Diaza-Crown Ether Carboxylic Acids", Inorg. Chem., 1988, 27, 3786-3789.

55. C.A. Chang, G. Lin, and D.E. Moss. "Determination of Methanesulfonyl Fluoride in Blood Matrix with a Fluoride Ion-Selective Electrode", Analyst, 1988, 113, 1485-1486.

56. V.K. Manchanda, C.A. Chang, and J. Peng. "Effect of Diluent on the Extraction of Lanthanide Complexes of Macrocyclic Ionophores", Solvent Extr. Ion Exch., 1988, 6, 835-857.

57. C.A. Chang, V.K. Manchanda, and J. Peng. "Kinetics of Solvent Extraction of Lanthanide Complexes of Macrocyclic Diaminodicarboxylic Acids", Solvent Extr. Ion Exch., 1989, 7, 413?433.

58. C.A. Chang, E. Wang, Z. Pang. "Interfacial Potential Difference for the Liquid/Liquid Ion Partition Process", J. Electroanal. Chem., 1989, 266, 143?155.

59. Z. Pang, E. Wang, and C.A. Chang. "The Study of the Kinetics of Ion Transfer at Liquid / Liquid Interfaces by the Linear Current Scanning Method", Chinese Science (B), 1990, 22?27.

60. R.C. Holz, S.L. Klakamp, C.A. Chang, and W. Dew. Horrocks, Jr. "Laser?Induced Europium(III) Luminescence and NMR Spectroscopic Characterization of Macrocyclic Diaza Crown Ether Complexes Containing Carboxylate Ligating Groups", Inorg. Chem., 1990, 29, 2651?2658.

61. C.A. Chang, H.G. Brittain, J. Telser, and M.F. Tweedle. "pH Dependence of Relaxivities and Hydration Numbers of Gadolinium(III) Complexes of Linear Aminocarboxylates", Inorg. Chem., 1990, 29, 4468-4473.

62. C.A. Chang. "Preclinical Studies with Gd(HP?DO3A)", in "New Developments in Contrast Agent Research", European Magnetic Resonance Forum, Proceedings of the 2nd Special Topic Seminar, Bordeaux, France, September 26-28, 1990, pp. 75-80.

63. C.A. Chang, H. Ji, and G. Lin. "Effects of Mobile Phase Composition on the Reversed Phase Separation of Di? and Tripeptides with Cyclodextrin Bonded Phase Columns", J. Chromatogr., 1990, 522, 143-152.

64. C.A. Chang. "Lanthanide Magnetic Resonance Imaging Contrast Agents: Thermodynamic, Kinetic, and Structural Properties of Lanthanide(III) Macrocyclic Complexes", Eur. J. Solid State Inorg. Chem., 1991, 28, 237-244.

65. R.C. Holz, C.A. Chang, and W. DeW. Horrocks, Jr. "Spectroscopic Characterization of the Europium(III) Complexes of a Series of N,N'?Bis(Carboxymethyl)Macrocyclic Ether? Bis(Lactones)", Inorg.Chem., 1991, 30, 3270-3275.

66. M.F. Tweedle, J.J. Hagan, S. Mantha, K. Kumar, and C.A. Chang. "Reaction of Gadolinium Chelates with Endogenously Available Ions", Mag. Reson. Imaging, 1991, 9, 409-415.

67. M.F. Tweedle, P. Wedeking, J. Telser, C.H. Sotak, C. A. Chang, K. Kumar, X. Wan, S.M. Eaton. "Dependence of MR Signal Intensity on Gd Tissue Concentration over a Broad Dose Range". Society of Magnetic Resonance in Medicine, Workshop on Contrast-Enhanced Magnetic Resonance, May 23-25, 1991; Napa, CA. pp. 23-29.

68. P. Wedeking, C.H. Sotak, J. Telser, K. Kumar, C.A. Chang, and M.F. Tweedle. "Dependence of MR Signal Intensity on Gd Tissue Concentration Over a Broad Dose Range", Mag. Reson. Med., 1991, 22, 191-194.

69. C.A. Chang, P.F. Sieving, A.D. Watson, T.M. Dewey, T.B. Karpishin, K.N. Raymond. "Ionic vs. Nonionic Magnetic Resonance Imaging Contrast Media: An Operational Definition", J. Mag. Reson. Imaging, 1992, 2, 95-98.

70. P. Wedeking, C.H. Sotak, J. Telser, K. Kumar, C.A. Chang, and M.F. Tweedle. "Quantitative Dependence of MR Signal Intensity on Tissue Concentration of Gd(HP-DO3A) in the Nephrectomized Rat." Mag. Reson. Imaging, 1992, 10, 97-108.

71. J.F. Carvalho, S.-H. Kim, and C. A. Chang. "Synthesis and Metal Complex Selectivity of Macrocyclic DTPA and EDTA Bis(Amide) Ligands." Inorg. Chem., 1992, 31, 4065-4068.

72. Xun Zhang, C.A. Chang, H.G. Brittain, J.M. Garrison, J. Telser, M.F. Tweedle. "pH Dependence of Relaxivities and Hydration Numbers of Gadolinium(III) Complexes of Macrocyclic Aminocarboxylates", Inorg. Chem., 1992, 31, 5597-5600.

73. K. Kumar, C.A. Chang, and M.F. Tweedle. "Equilibrium and Kinetic Studies of Lanthanide Complexes of Macrocyclic Polyaminocarboxylates", Inorg. Chem., 1993, 32, 587-593.

74. K. Kumar, K. Sukumaran, C.A. Chang, M.F. Tweedle, W.C. Eckelman. "True Tracer Radiolabeling of Gadolinium Complex of 10-(2-Hydroxypropyl)-1,4,7,10-tetraazacyclo-dodecane-1,4,7-triacetic Acid (HP-DO3A)." J. Labelled Compd. Radiopharm. 1993, XXXIII (6), 473-482.

75. C.A. Chang, L. Francesconi, M.F. Tweedle, et. al. "Metal Complexes for Magnetic Resonance Imaging: Synthesis and Characterizations of Fe(DO3A), Na[Fe(DOTA)], Gd(DO3A), and Na[Gd(DOTA)]", Inorg. Chem., 1993, 32, 3501-3508.

76. C.A. Chang. "Magnetic Resonance Imaging Contrast Agents, Design and Physicochemical Properties of Gadodiamide." Investigative Radiology, 1993, 28, S21-27.

77. S. Frey, C.A. Chang, and W. DeW. Horrocks, Jr. "Characterization of Lanthanide Complexes with a Series of Amide-based Macrocycles, Petential MRI Contrast Agents, Using Eu3+ Luminescence Spectroscopy and Molecular Mechanics". Inorg. Chem., 1994, 33, 2882-2889.

78. C.A. Chang, L.Francesconi, D. Dischino, M. Malley, J. Gougoutas, and M.F. Tweedle. "Synthesis, Stability, and Structures of Gd(III) and Y(III) Macrocyclic Polyaminocarboxylates". Inorg. Chem., 1994, 33, 3567-3575.

79. K. Kumar, C.A. Chang, S.C. Taylor, and M.F. Tweedle. "Partition Coefficients (log P) and HPLC Capacity Factors (k') of Some Gd(III) Complexes of Linear and Macrocyclic Aminocarboxylates", J. Liq. Chromatogr., 1994, 17, 3735-3746.

80. J.Varadarajan, S. Crofts, J.D. Fellmann, J.C. Carvalho, S. Kim, C.A. Chang, and A. Watson. "The Synthesis and Evaluation of Macrocyclic Gadolinium DTPA-bis(amide) Complexes as MRI Contrast Agents." Investigative Radiology, 1994, 29, S18-S20.

81. C.A. Chang. "Selectivity of Macrocyclic Aminocarboxylates for Alkaline Earth Metal Ions and Stability of Their Complexes", J. C. S. Dalton, 1996, 2347-2350.

82. C.A. Chang. "Dissociation Kinetics of Nickel(II), Zinc(II), and Cadmium(II) Complexes of 1,7?Diaza?4,10,13?trioxacyclopentadecane-N,N'?diacetic Acid and 1,10?Diaza?4,7,13,16- tetraoxacyclooctadecane?N,N'?diacetic Acid", J. Chin. Chem. Soc.(Taipei), 1996, 43, 419-426.

83. L. Wan, M.-Y. Luo, C.A. Chang, Y.-L. Lin, and E.-R. Chan. "Helicobacter pylori Induced Genes Expression in Human Gastric Cells Identified by mRNA differential Display", Biochem. Biophys. Res. Commun. 1996, 228, 484-488.

84. C.A. Chang. "Macrocyclic Lanthanide Coordination Chemistry", Proceedings of the National Science Council, R.O.C., 1997, 21, 1-13.

85. J.L. Laing, R.W. Taylor, and C.A. Chang. "The Acid-Catalyzed Dissociation of the Copper(II) and Lead(II) Complexes of Macrocyclic Diazapolyoxa-N,N'-diacetic Acid", J. C. S. Dalton Trans., 1997, 1195-1200.

86. C.A. Chang, F.-K. Shieh, Y.-L. Liu, Y.-H. Chen, H.-Y. Chen, and C.-Y. Chen. "Capillary Electrophoresis, Potentiometric and Luminescence Studies of Lanthanide(III) Complexes of 1,7-Dicarboxymethyl-1,4,7,10-tetraazacyclododecane (DO2A)", J. C. S. Dalton Trans., 1998, 3243-3248.

87. C.A. Chang, F.-K. Shieh, Y.-L. Liu, and C.-S. Chung. "Effects of Chain Length and Terminal N-alkylation on the Protonation Constants and Stability Constants of Some Transition Metal Complexes of Linear Tetraaza and Pentaaza Ligands", J. Chin. Chem. Soc.(Taipei), 1998, 45, 753-759.

88. E.-R. Chan, C.A. Chang, T.-Z. Wu, and Y.-L. Lin, "Effects of Recombinant Lysostaphin on Cytotoxicity and Interleukin-8 Level in Normal Human Epidermal Keratinocites Cell Lines", Biotech. Lett., 1998, 20, 1053-1056.

89. E.-R. Chan, M.-R. Pan, C.A. Chang, T.-Z. Wu, and Y.-B. Kuo, "A Synthetic Complement C1q-like Peptide Selectively Interacts with Immune Complexes", Biotech. Lett., 1998, 20, 1119-1123.

90. C.A. Chang, H.-Y. Chen, and C.-Y. Chen. "Determination of Stability Constants of Metal Ion Complexes by Capillary Electrophoresis." J. Chin. Chem. Soc.(Taipei), 1999, 46, 519-528.

91. C.C. Chang, C.A. Chang, and E.R. Chan. "Purification and Characterization of Neutral Sphingomyelinase from Helicobacter pylori", Biochemistry, 2000, 39, 4838-4845.

92. C.A. Chang and Y.-L. Liu. "Dissociation Kinetics of Ce(TETA)- and Ce(DOTA) -", J. Chin. Chem. Soc. (Taipei), 2000, 47, 1001-1006.

93. K.-T. Chen, J.-D. Lin, T.-C. Chao, C.A. Chang, H.-F. Weng, and E.-C. Chan. "Quantitative Monitoring of Gene Expression Patterns in Metastatic and Follicolar Human Thyroid Carcinoma Using a Complementary DNA Array", Thyroid, 2001, 11, 41-46.

94. C.A. Chang, Y.-L. Liu, C.-Y. Chen, X.-M. Chou, and J.-S. Ho. "Ligand Preorganization in Metal Ion Complexation: Molecular Mechanics/Dynamics, Kinetics and the Laser-Excited Luminescence Studies of Trivalent Lanthanide Complex Formation with Macrocyclic Ligands DOTA and TETA", Inorg. Chem. 2001, accepted for publication.

95. D.-L. Sheu, H.-A. Fan, K.-C. Hsu, C.A. Chang, Y.-S. Li, C.-C. Chiou, and E.-C. Chan. "Down-Regulation of Matrix Gla Protein Messenger RNA in Human Colorectal Adenocarcinomas", 2001, Int. J. Cancer, submitted.

96. E.-R. Chan, M.-Y. Lue, C.A. Chang, K.-T. Chen, K.-C. Hsu, H.-A. Fan. "Identification of Novel Genes that are Differentially Expressed in Human Colorectal Tumor Tissue", Life Sciences, 2001, submitted.

97. L. Wan, M.-Y. Luo, C.A. Chang, and E.-R. Chan. "Helicobacter pylori Infection Induces Genes Expression in Human Cultured Gastric Cells", Gut, 2001, submitted.

98. C.A. Chang and P.-Y. Kuan. "Effects of pH on the Rates of Phosphate Diester Hydrolysis by Macrocyclic lanthanide Complexes as Artificial Nucleases". 2001, submitted.

99. C.A. Chang and P.-Y. Kuan. "Macrocyclic Lanthanide Complexes as Artificial Nucleases: Ln(DO2A)+ and Ln(K21DA)+, Effects of pH and Ligand Structures." 2001, in preparation.

100. C.A. Chang and C.-L. Chen. "Dissociation Kinetics of Ln(DO2A)+." 2001, in preparation.

101. C.A. Chang and C.-L. Chen. "Kinetics of DNA/RNA Hydrolitic Scission by Macrocyclic Lanthanide Complexes Ln(DO2A)+." 2001, in preparation.

B. Non-refereed Reports and Papers (Excluding 60 industrial confidential reports).

1. L.M. Mayer, L.L. Schick, P.M. Rossi, H.H. Patterson, C.A. Chang, D.E. Bause, and L.K. Fink, Jr. "Analysis, Distribution, and Interactions of Chromium in the Aquatic Environment ", Completion Report, Land and Water Resources Center, University of Maine at Orono, April 1981, 66 pp.

2. C.A. Chang. "Some Stereochemical Aspects of Metal-Ligand Interactions", Conference Record, The 6th Annual Science, Engineering, and Technology Seminars, AACP, Houston, TX, May 1984, A1.4.1-A1.4.5.

3. C.A. Chang and J. Twu. "Complexation of a Crown Ether Oxycarboxylic Acid with Sodium, Potassium, and Calcium Ions", Conference Record, the 7th Annual Science, Engineering, and Technology Seminars, AACP, Houston, TX, May, 1985, B7.4.1-B7.4.3.

4. C.A. Chang, and L. Tan. "Selectivity for the separation of Substituted Benzoic Acids by Normal and Reversed Phase Liquid Chromatography", Conference Record, the 7th Annual Science, Engineering, and Technology Seminars, AACP, Houston, TX, May, 1985, C9.6.1-C9.6.4.

5. C.A. Chang. "Macrocyclic Lanthanide Coordination Chemistry", Proceedings of the First Chiao Tung University Tri-Campus Joint Conference, Shanghai/Sian/Hsin Chu, September 1996, 1-28.

6. C.A. Chang. "Metal Chelate Nuclear Medicine and Magnetic Resonance Imaging Contrast Agents", Research Progress Report, No. 852001NTD003, Atomic Energy Council, R.O.C., 1996.

7. C.A. Chang. "Polymeric Metal Chelate Magnetic Resonance Imaging Contrast Agents", Research Progress Report, Atomic Energy Council, R.O.C., 1999.

C. Book Reviews

1. C.A. Chang. Book Review: "Ion-Pair Chromatography: Theory and Biological and Pharmaceutical Applications", Ed. M.T.W. Hearn, Marcel Dekker, 1985,. J. Am. Chem. Soc., 1985,107, 6745-6746.

2. C.A. Chang. Book Review: "Introduction to Characterization and Testing of Catalysts", by J.R. Anderson and K.C. Pratt, Academic Press, 1985. J. Am. Chem. Soc., 1986, 106, 5379.

D. Other Articles

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ABSTRACTS AND RESEARCH PAPERS PRESENTED AT SCIENTIFIC MEETINGS :

1. C.A. Chang; B.E. Douglas. "Stereochemical Studies of Cobalt (III) Complexes of Sexidentate Aminopolyacids Using Carbon-13 Chemical Shifts", 176th ACS National Meeting, Miami Beach, FL, September 1978.

2. C.A. Chang; H.H. Patterson. "Determination of Chromium Speciation in Aquatic and Marine Environments", 179th ACS National Meeting, Houston, TX, March 1980.

3. C.A. Chang; H.H. Patterson; L.M. Mayer. "Estuarine Iron Flocculation: Colloid Chemistry and Effects on Pollutant Transport and Retention", 6th International Estuaries Research Conference, Gleneden Beach, OR, November 1981.

4. C.A. Chang; C.S. Huang. "Chromatographic Selectivities of Silica, Diamine and Metal Complex Bonded Phase Columns on Disubstituted Benzenes", 183rd ACS National Meeting, Las Vegas, NV, March 1982.

5. C.A. Chang. "New Ion -Selective Sequestering Agents Derived form Crown Ethers", 58th Annual Meeting of the Southwest and Rocky Mountain Division of AAAS, E1 Paso, TX, May 1982.

6. C.A. Chang. "Lanthanide Ion Selective Reagents Derived form Crown Ethers", 38th Southwest and 6th Rocky Mountain ACS Combined Regional Meeting, E1 Paso, TX , December 1982.

7. C.A. Chang; D.V. Marquez; R. Aguilar. "Implementation of a Digital Multi - Purpose Automatic Titrator ", 38th Southwest and 6th Rock Mountain ACS Combined Regional Meeting, E1 Paso , TX, December 1982.

8. C.A. Chang; C.S. Huang; J.M. Hoffer. "Determination of Silica Surface -Confined Cobalt by Energy - Dispersive X-Ray Fluorescence", 38th Southwest and 6th Rocky Mountain ACS Combined Regional Meeting, E1 Paso , TX, December 1982.

9. C.A. Chang. "Thermodynamic Parameters of Liquid Chromatographic Separations of Fructose, Glucose, and Sucrose with Amine and Cobalt(III) Complex Bonded Phase", 38th Southwest and 6th Rocky Mountain ACS Combined Regional Meeting, EI Paso, TX, December 1982.

10. C.A. Chang; C.S. Huang. "Characterization of Several Substitution-Inert Cobalt Complex Bonded Phases in Liquid Chromatographic Separations ", 1983 Pittsburgh Conference and Exposition on Analytical Chemistry and Applied Spectroscopy, Atlantic City, NJ, March1983.

11. C.A. Chang. "Liquid Chromatographic Retention Behavior of Some Disubstituted Benzenes in Polar Bonded Phase Columns",185th ACS National Meeting, Seattle, WA, March 1983.

12. C.A. Chang; M.E. Rowland. "1,10-Diaza-4,7,13,16-Tetraoxacyclooctadecane-N,N'-Diacetic Acid as a Potential Lanthanide Ion Selective Reagent", 185th ACS National Meeting, Seattle, Seattle, WA, March 1983.

13. C.A. Chang. "Normal Phase Separation of Chloroanilines and Nitroanilines with Strongly Hydrogen Bonded Mobile Phases", 39th Southwest ACS Regional Meeting, Tulsa, OK, December 1983.

14. C.A. Chang; C.S. Huang. "An Interaction Model for Liquid Chromatographic Normal Phase Retentions Involving Strong Hydrogen Bonding", 1984 Pittsburgh Conference and Exposition on Analytical Chemistry and Applied Spectroscopy, Atlantic City, NJ, March 1984.

15. V. Gonzalez; C.A. Chang. "Analysis of Histamine in Biological Fluids - A Comparison of Methods", 12th Annual MBRS Symposium, Washington, D.C., April 1984.

16. C.A. Chang. "Some Stereochemical Aspects of Metal - Ligand Interactions". 6th Science, Engineering, and Technology Seminars, Sponsored by the Association of American Chinese Professional at Houston, TX, May 1984.

17. C.A. Chang. "Effects of Solvent Composition on Liquid Chromatographic Separation Involving Hydrogen Bonding ", 7th Rocky Mountain Regional ACS Meeting, Albuquerque, NM, June 1984.

18. K.H. Pannell; C.A. Chang. "Selective of Silicon Based Ionophores(Silacrowns) for K and Na Complexation Transport", 7th International; Symposium on Organosilicon Chemistry, Kyoto, Japan, September 1984.

19. C.A. Chang. "Potential Macrocyclic Lanthanide Ion Selective Reagents", 40th Southwest Regional ACS Meeting, Lubbock, TX, December 1984.

20. C.A. Chang. "Use of Substitution-Inert Metal Complexes in High Performance Liquid Chromatography", 1985 Pittsburgh Conference and Exposition on Analytical Chemistry and Applied Spectroscopy, New Orleans, LA, February 1985.

21. C.A. Chang; K. Fong. "Ion Chromatography with Substitution-Inert Metal Complex Mobile Phases", 13th Annual MBRS Symposium, Miami, FL, March 1985.

22. C.A. Chang. "Selectivity for the Separation of Substituted Benzoic Acids by Ion-Pair Chromatography ", 7th Science, Engineering , and Technology Seminars, sponsored by the Association of American Chinese Professionals at Houston, TX, May 1985.

23. C.A. Chang; J. Twu. "Complexation of Silyl Crown Ethers with Some Metal Ions", 7th Science, Engineering, and Technology Seminars, sponsored by the Association of American Chinese Professionals at Houston, TX, May 1985.

24. C.A. Chang. "1,7-Diaza-4,10,13-Trioxacyclopentadecane-N,N-Diacetic Acid: A Reagent Selective for Europium (III) Among Lanthanide Ions", 10th International Symposium of Macrocyclic Chemistry, Provo, UT, August 1985.

25. C.A. Chang. "Normal and Reversed-Phase Liquid Chromatographic Separations of Substituted Isomeric Benzoic Acids and Phenols", 1986 Pittsburgh Conference and Exposition on Analytical Chemistry and Applied Spectroscopy, Atlantic City, NJ, March 1986.

26. C.A. Chang. "Recent Advances on Lanthanide-Macrocycle Chemistry", 19th Society of Western Analytical Professors (SWAP) Meeting, Flagstaff, AZ, January 1986.

27. C.A. Chang. "Concerning the Effects of Solvent on the Separations with Cyclodextrin Bonded Phase Columns", 10th International Symposium on Column Liquid Chromatography, San Francisco, CA, May 1986.

28. C.A. Chang. "High Performance Liquid Chromatography of Polymers", 10th International Symposium on Column Liquid Chromatography, San Francisco, CA, May 1986.

29. C.A. Chang; V.O. Ochaya. "Metal Complex Formation With 1,7-Diaza -4,10,13-Trioxacyclopentadecane-N,N' -Diacetic Acid", 17th Rare Earth Research Conference, McMaster University, Hamilton, Canada, June 1986.

30. C.A. Chang; V.C. Sckhar. "Dissociation Kinetics of 1,7-Diaza-4,10,13-Trioxacyclo-pentadecane-N,N'-Diacetic Acid Complexes of Lanthanides", 17th Rare Earth Research Conference, McMaster University, Hamilton, Canada, June 1986.

31. C.A. Chang; V.K. Manchanda. "Mixed Ligand Complexes of Lanthanides with Macrocyclic and Opened-Chained Polyaminopolycarboxylic Acid and Acetylacetone ", 17th Rare Earth Research Conference, McMaster University, Hamilton, Canada ,June 1986.

32. C.A. Chang; V.K. Manchanda. "Solvent Extraction Studies of La (III) and Nd (III) with Ionizable Macrocyclic Ligands and Thenoyltrifluoroacetone", 17th Rare Earth Research Conference, McMaster University, Hamilton, Canada, June 1986.

33. M.P. Eastman; C.A. Chang. "Weak Complexation of Nitroxide Radicals by Cyclodextrin", 42nd Southwest Regional American Chemical Society Meeting, Houston, TX, November 1986.

34. C.A. Chang. "Comparison of Substitution-Inert Metal Complex and Cyclodextrin Bonded Phase Columns for Liquid Chromatography", 1987 Pittsburgh Conference and Exposition on Analytical Chemistry and Applied Spectroscopy, Atlantic City, NJ, March 1987.

35. C.A. Chang. "The Second Generation Bonded Phase for Modern Liquid Chromatography", 11th International Symposium on Column Liquid Chromatography, Amsterdam, The Netherlands, June 1987.

36. C.A. Chang; H. Ji. "Effect of Mobil Phase Composition on the Revered-Phase Separation of Peptides with Cyclodextrin Bonded LC Columns", 11th International Symposium on Column Liquid Chromatography, Amsterdam, The Natherlands, June 1987.

37. C.A. Chang; J. Peng. "Kinetic Control of Chelate Extraction Selectivities of Lanthanides with Ionizable Macrocyclic Reagents", 12th International Symposium on Macrocyclic Chemistry, Hiroshima, Japan, July 1987.

38. C.A. Chang. "Nonionic NMR Contrast Agents", 1988 Florida Conference on Chemistry in Biotechnology, Gainsville, Florida, April 1988.

39. C.A. Chang; M.F. Tweedle. "New Nonionic Gd Complexes as MRI Contrast Agents", 2nd European Congress of NMR in Medicine and Biology, Berlin, Germany, June 1988.

40. R.C. Holz; C.A. Chang; W. DeW. Horrocks, Jr. "Laser-Induced Europium(III) Luminescence Spectroscopy of Macrocyclic Polycarboxylic Acid Complexes", 195th ACS National Meeting, Toronto, Canada, June 1988.

41. C.A. Chang; M.F. Tweedle. "New Nonionic Gadolinium Complexes as MRI Contrast Agents", 7th Annual Meeting of Society of Magnetic Resonance in Medicine, San Francisco, California, August 1988.

42. C.A. Chang. "Stability of Lanthanide Complexes of Macrocyclic Ligands Derived form EDTA", 13th International Symposium on Macrocyclic Chemistry, Hamburg, Germany, September 1988.

43. C.A. Chang. "Equilibria and Dissociation Kinetics of Lanthanide Complexes of Some Diaza-Crown Ether Carboxylic Acids", 13th International Symposium on Macrocyclic Chemistry, Hamburg, Germany, September 1988.

44. L. Francesconi; C.A. Chang. "Metal Complexes for Magnetic Resonance Imaging ", 196th ACS National Meeting, Los Angeles, September 1988.

45. R.C. Holz; C.A. Chang; W. DeW. Horrocks, Jr. "Laser-Induced Europium (III) Luminescence Spectroscopy of Macrocyclic Polycarboxylic Acid Complexes", 18th Rare Earth Research Conference, Lake Geneva, Wisconsin, September 1988.

46. C.A. Chang. "Development of Nonionic Gadolinium Chelates for Use as Contrast Agents in Magnetic Resonance Imaging (MRI)", 197th ACS National Meeting at Dallas, April 1989.

47. C.A. Chang; K. Kumar. "Nonionic Gadolinium(III) Macrocyclic Complexes as Magnetic Resonance Imaging Contrast Agents", 14th International Symposium on Macrocyclic Chemistry at Townsville, Australia, June 1989.

48. J. Telser; C.A. Chang. "Gadolinium(III) Chelate Complexes as Magnetic Resonance Imaging (MRI) Contrast Agents: pH Dependence of the T1 Relaxivity and Number of Coordinated Water Molecules", 4th International Conference on Bioinorganic Chemistry at Boston, July 1989.

49. M.F. Tweedle; C.A. Chang. "Nonionic Macrocyclic Gadolinium(III) Complexes as Contrast Agents in Magnetic Resonance Imaging", 27th International Conference on Coordination Chemistry, Gold Coast, Australia, July 1989.

50. C.A. Chang. "Relaxivities of Potential Gd(III) MRI Contrast Agents: pH Dependence studies" 8th Annual Meeting of Society of Magnetic Resonance in Medicine at Amsterdam, August 1989.

51. C.A. Chang; M.F. Tweedle. "New Nonionic Macrocyclic Gadolinium Complexes", 8th Annual Meeting of Society of Magnetic Resonance in Medicine at Amsterdam, August 1989.

52. P. Wedeking; M.F. Tweedle; C.A. Chang. "Biodistribution and Excretion of New Gd?Complexes in Mice", 8th Annual Meeting of Society of Magnetic Resonance in Medicine at Amsterdam, August 1989.

53. M.F. Tweedle; C.A. Chang. "Gadolinium Chelates for Cerebral and Myocardial Imaging", Contrast Media Research 1989, Sydney, Australia.

54. M.F. Tweedle; C.A. Chang. "Physico?Chemical Properties and Biodistribution of Gd Chelates", Contrast Media Research 1989, Sydney, Australia.

55. M.F. Tweedle; C.A. Chang. "Synthesis and Characterization of Macrocyclic Gd(III) Complexes as Contrast Agents for Magnetic Resonance Imaging", 1989 International Chemical Congress of Pacific Basin Societies at Hawaii, December 1989.

56. M.F. Tweedle; P. Wedeking; C.A. Chang. "Comparison of MRI Signal Intensity with Concentration of [Gd] in heart in Nephrectomized Rats", 9th Annual Meeting of Society of Magnetic Resonance in Medicine at New York City, August 1990.

57. C.A. Chang; K. Kumar; M.F. Tweedle. "Physical Properties of Gd(HP?DO3A) ? A MRI Contrast Agent", 9th Annual Meeting of Society of Magnetic Resonance in Medicine at New York City, August 1990.

58 K. Kumar; C.A. Chang. "Lanthanide Magnetic Resonance Imaging Contrast Agents: Formation and Dissociation Reaction Kinetics of Some Gd(III) and Ce(III) Complexes of Macrocyclic Aminocarboxylates", 28th International Conference on Coordination Chemistry at Jena, DDR, August 1990.

59. C.A. Chang; M.F. Tweedle. "Preclinical Studies with Gd(HP?DO3A)", European Workshop on Nuclear Magnetic Resonance in Medicine, 2nd Special Topic Seminar: New Development in Contrast Agents Research. Bordeaux, France, September 26?28, 1990.
[Invited Lecture].

60. C.A. Chang. "Lanthanide Magnetic Resonance Imaging Contrast Agents: Thermodynamic, Kinetic, and Structural Properties of Lanthanide(III) Macrocyclic Complexes", 1stƒInternational Conference on f?Elements at Leuven, Belgium, September 4-7, 1990. [Invited Lecture].

61. C.A. Chang; K.N. Raymond. "Ionic vs. Nonionic MR Contrast Media: A Question of Scientific Definition". Society of Magnetic Resonance Imaging at Chicago, IL, April 16, 1991.

62. M.F. Tweedle; C.A. Chang. "Dependence of MR Signal Intensity on Gd Tissue Concentration over a Broad Dose Range". Society of Magnetic Resonance in Medicine, Workshop on Contrast-Enhanced Magnetic Resonance, Napa, CA, May 23-25, 1991.

63. C.A. Chang. "Equilibria, Kinetics, and Structural Properties of Macrocyclic Lanthanide Complexes", 19th Rare Earth Research Conference at Lexington, Kentucky, July?14?19, 1991. [Invited Lecture]

64. C.A. Chang. "Chelation Chemistry of MRI Contrast Media", 10th Annual Meeting of the Society of Magnetic Resonance in Medicine at San Francisco, August, 10-16, 1991.
[Invited Lecture].

65. C.A. Chang. "Metal Complexes in Magnetic Resonance Imaging: Rare Earth Complexes as a Case Study." 203rd ACS National Meeting in San Francisco, April 5-10, 1992.
[Invited Lecture].

66. S.K. Kim; C.A. Chang. "Synthesis and Thermodynamic Characterization of Macrocyclic Gadolinium DTPA and EDTA Bis(Amide) Complexes." 203rd ACS National Meeting in San Francisco, April 5-10, 1992.

67. J. Carvalho; C.A. Chang. "Metal Complex Selectivity of Macrocyclic DTPA and EDTA Bis(Amide) Ligands." 11th Annual Meeting of the Society of Magnetic Resonance in Medicine at Berlin, August, 1992.

68. J. Lai; C.A. Chang. "HPLC Study to Separate MnDPDP and Possible In Vivo Metabolites in Human Plasma." 19th Annual Meeting of the Federation of Analytical Chemistry and Spectroscopy Societies, Philadelphia, September 20-25, 1992.

69. C.A. Chang. "Macrocyclic Lanthanide Complexes as Magnetic Resonance Imaging (MRI) Contrast Agents." 1996 Symposium on Isotope and Radiation Application, Lungtan, Taiwan, April 26-27, 1996.

70. C.A. Chang. "Metal Complexes as Magnetic Resonance Imaging (MRI) Contrast Agents." Second APSB International Symposium & Workshop, Hong Kong, July 8-11, 1996.

71. C.A. Chang. "Metal Chelate Nuclear Medicine and Magnetic Resonance Imaging Contrast Agents", 1996 Research Conference, Atomic Energy Council, R.O.C., Lung-Tan, Taiwan, November 20-21, 1996.

72. C.A. Chang. "Capillary Electrophoresis, Potentiometric, Luminescence, and Molecular Mechanics Studies of Lanthanide(III) Complexes of Some Macrocyclic Tetraazapolycarboxylate Ligands", 1996 Annual Meeting of the Chinese Chemical Society (Taipei), Kaohsiung, Taiwan, December 6-8, 1996. [Invited Lecture].

73. Y.-H. Chen and C.A. Chang. "Aqueous Solution Properties of Eu3+-DO2A System: A Laser-Excited Luminescence Study." 1996 Annual Meeting of the Chinese Chemical Society (Taipei), Kaohsiung, Taiwan, December 6-8, 1996.

74. F.-K. Shieh, Y.-L. Liu and C.A. Chang. "Effects of Chain Length and Terminal N-alkylation on the Protonation Constants and Stability Constants of Some Transition Metal Complexes of Linear Tetraaza and Pentaaza Ligands." 1996 Annual Meeting of the Chinese Chemical Society (Taipei), Kaohsiung, Taiwan, December 6-8, 1996.

75. Huan-Yuan Chen, Chang-Yuh Chen and C.A. Chang. "Determination of Stability Constants of Metal Ion Complexes by Capillary Electrophoresis." 1996 Annual Meeting of the Chinese Chemical Society (Taipei), Kaohsiung, Taiwan, December 6-8, 1996.

76. Xiu-Mei Chou, Jyh-Shyong Ho and C. Allen Chang. "Preorganization in Metal Ion Complexation: A Molecular Mechanics Study of Lanthanide Complex Formation with Macrocyclic Ligands DOTA and TETA." 1996 Annual Meeting of the Chinese Chemical Society (Taipei), Kaohsiung, Taiwan, December 6-8, 1996.

77. C.A. Chang and Y.-H. Chen. "Laser Luminescence Study of Aqueous Solution Properties of Eu3+-DO2A System." 213th ACS National Meeting at San Francisco, April 13-17, 1997.

78. M.-R. Pan, C.-H. Lin, C.A. Chang, and E.-C. Chan. "Development of C1q Like Peptide for Using as an Universal Tracer in Immunoassay." 1997 Annual Combined Biomedical Conference at Taipei, Taiwan, April 19-20, 1997.

79. L. Wan, M.-Y. Lue, C.A. Chang, Y.-L. Lin, and E.-C. Chan. "Helicobacter Pylori Induced Genes Expression in Human Gastric Cells Identified by mRNA Differential Display." 1997 Annual Combined Biomedical Conference at Taipei, Taiwan, April 19-20, 1997.

80. C.A. Chang. "Capillary Electrophoresis and Laser-Excitation Fluorescence Studies of Lanthanide Complex Equilibria". 6th International Seminars on Electroanalytical Chemistry (6th ISEC), Changchun, China, Oct. 10-12, 1997 (Invited Lecture).

81. C.A. Chang." The Physicoanalytical Chemistry of Lanthanide and Transition Metal Magnetic Resonance Imaging Contrast Agents". 7th International Beijing Conference and Exhibition on Instrumental Analysis (7th BCEIA), Shanghai, China, Oct. 14-17, 1997 (Invited Lecture).

82. S.-P. Cheng, E.-C. Chan and C.A. Chang. "The Use of Piezoelectric Crystal Sensor for the Diagnosis of Human Helicobacter Pylori". 1997 Annual Meeting of the Chinese Chemical Society (Taipei), Hsinchu, Taiwan, December 5-7, 1997.

83. M.-R. Pan, Y.-B. Kuo, C.-H. Lin, E.-C. Chan and C.A. Chang. "Isolation of Porcine Complement C1q and the Development of a C1q-like Peptide for Immunoassay".. 1997 Annual Meeting of the Chinese Chemical Society (Taipei), Hsinchu, Taiwan, December 5-7, 1997

84. Chang-Yuh Chen and C.A. Chang. "Determination of Stability Constants of Metal Ion Complexes by Capillary Electrophoresis. II. The Method of Metal-Ligand Double Exchange." 1997 Annual Meeting of the Chinese Chemical Society (Taipei), Hsinchu, Taiwan, December 5-7, 1997.

85. S.-P. Cheng, E.-C. Chan and C.A. Chang. "Development of a Piezoelectric Immunosensor for the Detection of Anti-Helicobacter Pylori Antibodies". 1998 The Thirteenth Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, April 18-19, 1998.

86. C.A. Chang, Y.-L. Liu and C.-Y. Chen. "Kinetics and the Laser-Excited Luminescence Study of Solution Properties of the Ce3+/Eu3+-TETA/DOTA Systems". 1998 Annual Meeting of the Chinese Chemical Society (Taipei), Chia-Yi, Taiwan, November 27-29, 1998.

87. D.-L. Shi, E.-C. Chan and C.A. Chang. "Expression of the Matrix Gla Protein in Colorectal Tumor Cells". 1999 The Fourteenth Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, April 10-11, 1999.

88. Y.-L. Yen, C.-C. Chiou, C.A. Chang, and E.-C. Chan. "The Study of Melanoma Antigen Gene Expression in Colorectal Cancer by RT-PCR". 1999 The Fourteenth Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, April 10-11, 1999.

89. D.L. Sheu, C.A. Chang, and E.-C. Chan. "Expression of Cell Cycle Regulator Genes CDC25, Wee1HU, and Proto-Oncogen C-MYC in Human Colonrectal Cancer". 2000 The Fifthteenth Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March 25-26, 2000.

90. K.-T. Chen, C.A. Chang, and E.-C. Chan. "Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Array in Metastatic and Human Thyroid Follicular Tissues". 2000 The Fifthteenth Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March 25-26, 2000.

91. K.-T. Chen, J.D. Lin, M.J. Liou, C.A. Chang, C.C. Chiou, and E.-C. Chan. "Detection of Distinctive Gene Expression in Thyroid Follicular Carcinoma Cell Line by Using cDNA Array Technology". The Sixteenth Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March 24-25, 2001.

92. J.W. Hsieh, J.D. Lin, M.J. Liou, C.A. Chang, and E.-C. Chan. "A Rapid Modified Method of Polymerase Chain Reaction for Detection of Point Mutated-Iodide Transport Gene". The Siteenth Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March 24-25, 2001.

PLENARY LECTURES AND SEMINARS

I. Industry, Government Research Institutes, and High Schools

1. Mobay Chemical Corporation, Pittsburgh, PA (7/1978).
2. Stauffer Chemical Company, Westport, CT (3/1979).
3. Exxon Chemical Company, Florham Park, NJ (3/1979).
4. Hooker Chemical Company, Buffalo, NY (8/1979).
5. Ballard Research Incorporated, Vancouver, BC, Canada (6/1985).
6. Aluminum Company of America, Pittsburgh, PA (9/1986).
7. Syntex Corporation, Palo Alto, CA (5/1987).
8. Squibb Institute for Medical Research, New Brunswick, N J (5/1987).
9. Nang Kuang Pharmaceutical Co., Ltd., Tainan, Taiwan (11/1992).
10. Development Center for Biotechnology, Taipei, Taiwan (11/1992).
11. National Laboratories of Food and Drugs, Taipei, Taiwan (11/1992).
12. Institute of Nuclear Energy Research, Lung-Tan, Taiwan (11/17/1994).
13. Institute of Nuclear Energy Research, Lung-Tan, Taiwan (11/25/1994).
14. Everlight Chemical Industrial Corporation, Taipei, Taiwan (3/9/1995).
15. National Institute of Preventive Medicine, Taipei, Taiwan (6/15/1995).
16. ¤¤¿³¬ì§Þ¤å±Ð°òª÷·|, "Â૬²£·~¤§±o³Ó¯µ³Z", Taichung, Taiwan (3/7/1997).
17. Chemical Taipei Club, "Biotechnology Market Analysis", Taipei, Taiwan (2/20/1998).
18. National Experimental High School at Science-Based Industrial Park, "Biotechnology: The Past, The Present, and The Future", Hsinchu, Taiwan (3/26/1998).
19. Industrial Development Bureau, "Biological Science and Technology Market Analysis", Taipei, Taiwan (5/18/1998)
20. Hsinchu High School, "Biotechnology: The Past, The Present, and The Future", Hsinchu, Taiwan (6/13/1998).
21. Industrial Development Bureau, "Biological Science and Technology Market Analysis", Hsinchu, Taiwan (10/12/1998)
22. National Science and Technology Museum. "Biotechnology and Daily Living". Kaoshiung, Taiwan (12/19/1998).
23. ¦Û±j¤u·~¬ì¾Ç°òª÷·|, ²MµØ¤j¾Ç, "Biological Science and Technology Market Analysis", Hsinchu, Taiwan (07/08/1999)
24. To-fen Rotary Club, "Biotechnology and Daily Living". To-fen, Taiwan (01/27/2000).
25. ¦Û±j¤u·~¬ì¾Ç°òª÷·|, ²MµØ¤j¾Ç, "Biological Science and Technology Market Analysis", Hsinchu, Taiwan (09/06/2000)
26. Bureau of Labor Training, "The Strategy and Opportunity of Biotechnology Industry in Taiwan", Kaoshiung, Taiwan (11/29/2000)
27. Hai-Shan High School, "The Strategy and Opportunity of Biotechnology Industry in Taiwan", Taipei, Taiwan (11/30/2000)

II. Universities

1. Wellesley College, Department of Chemistry, Wellesley, MA (5/1978).
2. Clark University, Department of Chemistry, Worchester, MA (1/1979).
3. University of Pittsburgh at Johnstown, Department of Chemistry, PA (2/1979).
4. University of Dallas, Department of Chemistry, Irving, TX (1/1980).
5. University of Maine, Department of Chemistry, Orono, ME (2/1980).
6. University of Dayton, Department of Chemistry, Dayton, OH (3/1980).
7. University of Texas at El Paso, Department of Chemistry, El Paso, TX (3/1980).
8. University of Missouri, Department of Chemistry, St. Louis, MO (3/1980).
9. Clemson University, Department of Chemistry, Clemson, SC (3/1980).
10. University of Texas at Arlington, Department of Chemistry, Arlington, TX (10/1981).
11. University of Texas at Dallas, Department of Chemistry, Richardson, TX (10/1981).
12. University of New Mexico, Department of Chemistry, Albuquerque, NM (2/1982).
13. Texas Tech University Health Science Center, TX (8/1982).
14. East Texas State University, Department of Chemistry, Commerce, TX (9/1982).
15. North Texas State University, Department of Chemistry, Denton, TX (9/1982).
16. University of Texas at El Paso, Department of Chemistry, El Paso, TX (10/1982).
17. University of Pittsburgh, Department of Chemistry, Pittsburgh, PA (3/1983).
18. New Mexico State University, Department of Chemistry, Las Cruces, NM (9/1983).
19. Texas Tech University, Department of Chemistry, Lubbock, TX (2/1984).
20. University of Kentucky, Department of Chemistry, Lexington, KY (11/1984).
21. University of Texas at San Antonio, Department of Chemistry, San Antonio, TX (3/1985).
22. University of Hawaii, Department of Chemistry, Honolulu, HI (2/1986).
23. Pennsylvania State University, Department of Chemistry, University Park, PA (3/1986).
24. University of Pittsburgh, Department of Chemistry, Pittsburgh, PA (3/1986).
25. Shanghai University of Technology, Department of Chemistry, Shanghai, China (7/1987).
26. Changchun Institute of Applied Chemistry, Academia Sinica, China (7/1987).
27. Nankai University, Department of Chemistry, Tienjing, China (8/1987).
28. Institute of Chemistry, Academia Sinica, Beijing, China (8/1987).
29. National Tsing Hua University, Department of Chemistry, Hsinchu, Taiwan (7/1989).
30. Institute of Chemistry, Academia Sinica, Taipei, Taiwan (7/1989).
31. University of Laussane, Department of Chemistry, Laussane, Switzerland (1/1990).
32. University of Texas at El Paso, Department of Chemistry, El Paso, TX (9/1991).
33. Pennsylvania State University, Department of Chemistry, University Park, PA (10/1991).
34. University of Texas at Dallas, Department of Chemistry, Richardson, TX (10/1991).
35. San Jose State University, Department of Chemistry, San Jose, CA (3/1992).
36. Institute of Chemistry, Academia Sinica, Taipei, Taiwan (11/1992).
37. National Taiwan University, Department of Chemistry, Taipei, Taiwan (11/1992).
38. National Tsing Hua University, Department of Chemistry, Hsinchu, Taiwan (11/1992).
39. National Chung Hsing University, Department of Chemistry, Taichong, Taiwan (11/1992).
40. National Tsing Hua University, Department of Chemistry, Hsinchu, Taiwan (3/1993).
41. National Chiao Tung University, Department of Applied Chemistry, Hsinchu, Taiwan (3/1992).
42. National Cheng Kung University, Department of Chemistry, Tainan, Taiwan (5/1993).
43. Shanghai Jiao Tong University, Department of Applied Chemistry, Shanghai, China (4/5/1994).
44. Changchun Institute of Applied Chemistry, Academia Sinica, China (4/7/1994).
45. Beijing University, Department of Chemistry, Beijing, China (4/12/1994).
46. National Tsing Hua University, Institute of Life Sciences, Hsinchu, Taiwan (12/15/1994).
47. Shanghai Jiao Tong University, Department of Applied Chemistry, Shanghai, China (1/18/1995).
48. Shanghai Research Institute of Chemical Industry, Shanghai, China (1/19/1995).
50. Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan (2/20/1995).
51. National Chung Hsing University, Department of Chemistry, Taichong, Taiwan (2/22/1995).
52. National Chiao Tung University, Institute of Management of Technology, Hsinchu, Taiwan (2/28/1995).
53. Everlight Chemical Industrial Corporation, Taipei, Taiwan (3/9/1995).
54. National Science Council, "Biotechnology Market Analysis",Taipei, Taiwan (4/27/1995).
55. Industrial Technology Research Institute, Union Chemical Laboratories/Chinese Chemical Society, "Biotechnology: The Past, The Present, and The Future", Hsinchu, Taiwan (5/5/1995).
56. Chang Gung Medical College, Department of Medical Technology, "In Vivo Medical Diagnostic Instrumentation: Principles and Applications. I. X-Ray Radiography and Computed Tomography", Taipei, Taiwan (5/9/1995).
57. Chang Gung Medical College, Department of Medical Technology, "In Vivo Medical Diagnostic Instrumentation: Principles and Applications II. Magnetic Resonance Imaging, Single-Photon Emission Computed Tomography, and Positron Emission Tomography", Taipei, Taiwan (5/16/1995).
58. National Tsing Hua University, Department of Chemistry, "Design Principles and Applications of Magnetic Resonance Imaging Contrast Agents", Hsinchu, Taiwan (5/17/1995).
59. Chung Yuan Christian University, Department of Chemistry, "Metal Complexes As Magnetic Resonance Imaging Contrast Agents", Chungli, Taiwan (10/04/1995).
60. Kaohsiung Medical College, Department of Chemistry, "Metal Complexes As Magnetic Resonance Imaging Contrast Agents", Kaohsiung, Taiwan (11/10/1995).
61. National Chiao Tung University, Institute of Management Science, "Biotechnology: The Past, The Present, and The Future", Taipei, Taiwan (11/27/1995).
62. Fu Jen Catholic University, Department of Chemistry, "Metal Complexes as Magnetic Resonance Imaging Contrast Agents", Taipei, Taiwan (3/14/1996).
63. National Chiao Tung University, Department of Electronics Engineering, "Biotechnology: The Past, The Present and The Future", Hsinchu, Taiwan (3/22/1996).
64. Tamkang University, Department of Chemistry, "The Coordination Chemistry of Macrocyclic Lanthanide Complexes", Taipei, Taiwan (3/25/1996).
65. National Chiao Tung University, Department of Electronic Physics. "Biotechnology: The Past, The Present and The Future", Hsinchu, Taiwan (4/18/1996).
66. National Yang Ming University, School of Medical Technology and Engineering, "Metal Complexes as Magnetic Resonance Imaging Contrast Agents", Taipei, Taiwan (6/05/1996).
67. National Cheng Kung University, Department of Biology "Biotechnology: The Past, The Present, and The Future", Tainan, Taiwan (10/29/1996).
68. Pig Research Institute, "Biotechnology: The Past, The Present, and The Future", Chunan, Taiwan (12/31/1996).
69. Taipei Medical College, "Biotechnology: The Past, The Present, and The Future", Taipei, Taiwan (3/10/1997).
70. Institute of Chemistry, Academia Sinica, "Design of Magnetic Resonance Imaging Contrast Enhancement Agents and Radiopharmaceuticals - Ligand Pre-organization in Metal Complexation", Taipei, Taiwan (3/13/1997).
71. National Taiwan University, Department of Chemistry, "The Physicoanalytical Chemistry of Magnetic Resonance Imaging Contrast Enhancement Agents", Taipei, Taiwan (3/20/1997).
72. National Sun Yat-Sen University, College of Management. "¥Íª«¬ì§Þ²£·~¤§¤H¤O¸ê·½°ö¨|", Kaohsiung, Taiwan (12/05/1997).
73. National Sun Yat-Sen University, Department of Chemistry, "Metal Complexes As Magnetic Resonance Imaging Contrast Agents", Kaohsiung, Taiwan (03/11/1998).
74. National Tsing Hua University, College of Life Sciences, "¥Íª«¬ì§Þ²£·~¤§¤H¤O¸ê·½°ö¨|", Hsinchu, Taiwan (06/06/1998).
75. National Taiwan University, Department of Chemistry. "Recent Advances in Macrocyclic Lanthanide Coordination Chemistry." Taipei, Taiwan (10/21/1998).
76. Veterans General Hospital, Department of Medical Research and Education. "Metal Complexes as Magnetic Resonance Imaging Contrast Agents and Artificial Ribonucleases." Taipei, Taiwan (11/13/1998).
77. National Chiao Tung University, Department Industrial Engineering and Management. "Biotechnology: The Past, The Present, and The Future", Hsinchu, Taiwan (12/15/1998).
78. Kaohsiung Medical College, "Biotechnology: The Past, The Present, and The Future", Kaohsiung, Taiwan (07/03/1999).
79. National Cheng Kung University, Institute of Biotechnology, "The Strategies and Future of Biotechnology in Taiwan", Tainan, Taiwan (11/25/1999).
80. National Changhua University of Education, Department of Chemistry, "Metal Complexes as Magnetic Resonance Imaging Contrast Agents and DNA/RNA Cleavage Agents", Chia-Yi, Taiwan (03/06/2000).
81. Taipei Medical College, "Biotechnology: The Past, The Present, and The Future", Taipei, Taiwan (03/08/2000).
82. National Chung Hsin University, Institute of Molecular Biology, "Biotechnology: The Past, The Present, and The Future", Taipei, Taiwan (3/17/2000).

III. Conferences (Only invited talks)

1. 1st International Conference on f-Elements, Leuven, Belgium (9/1990).
2. European Workshop on Nuclear Magnetic Resonance in Medicine, 2nd Special Topic Seminar: New Developments in Contrast Agents Research. Bordeaux, France (9/1990).
3. 19th Rare Earth Research Conference, Lexington, KY (7/1991).
4. 10th Annual Meeting of the Society of Magnetic Resonance in Medicine, San Francisco, CA (8/1991).
5. 203rd ACS National Meeting, San Francisco, CA (4/1992).
6. 6th International Seminars on Electroanalytical Chemistry (6th ISEC) Changchun, China, Oct. 10-12, 1997.
7. 7th International Beijing Conference and Exhibition on Instrumental Analysis (7th BCEIA) Shanghai, China, Oct. 14-17, 1997.
8. 2nd Symposium on Molecular Biotechnology, Taipei, Feb. 14-15, 1998.
9. "Biotechnology in Taiwan". Taiwan-Australia Collaboration Research Symposium, Taipei, Taiwan, April 8-9, 1999.
10. "Recent Advances of Biotechnology R&D in National Chiao Tung University". °ª¬ì§Þ²£·~µo®iÁͶպ[§Þ³N¦X§@»P§ë¸ê¬ã°Q·|, Taipei, Taiwan, May 1, 1999.
11. "Strategies for Biotechnology Industry and Academic Institutions in Taiwan." Annual Conference of Midwest Chinese American Science & Technology Association, St. Louis, MO, U.S.A. June 11-13, 1999.
12. "Metal Complexes as Magnetic Resonance Imaging Contrast Agents and DNA/RNA Cleavage Agents", Annual Conference of Midwest Chinese American Science & Technology Association, St. Louis, MO, U.S.A. June 11-13, 1999.
13. "Strategies for Biotechnology Industry and Academic Institutions in Taiwan." 4th International Conference, American Chinese Pharmaceutical Association, NIH, Bethesda, MD, U.S.A. October 2-3, 1999
14. "Metal Complexes as Magnetic Resonance Imaging Contrast Agents and DNA/RNA Cleavage Agents", Annual Conference of Chinese Pharmaceutical Chemistry Association, Ping Tong, Taiwan, July 12-13, 2000.

IV. Conference/Symposium organized

1. The 3rd International Symposium of Worldwide Chinese Scholar on Analytical Chemistry (²Ä¤T©¡°ê»ÚµØ¸Ç¾ÇªÌ¤ÀªR¤Æ¾Ç¬ã°Q·|). Hong Kong, December 16-19, 1998.

2. Taiwan-Australia Collaboration Research Symposium (¥x¿D¬ì§Þ¦X§@¬ã°Q·|). Bio-Medical Technologies Session, Taipei, Taiwan, April 8-9, 1999.

3. °ª¬ì§Þ²£·~µo®iÁͶպ[§Þ³N¦X§@»P§ë¸ê¬ã°Q·|,¥Í¤Æ²Õ. ¥x¥_, ¥xÆW, May 1, 1999.

SEMINAR TOPICS AND ABSTRACTS

1.
Biotechnology : The Past, The Present, and The Future
(Biotechnology Market Analysis)

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(¥Íª«¬ì§Þ²£·~¤ÀªR)

The field of biotechnology covers both biological sciences and technologies. The unique feature of modern biotechnology is that laboratory research and development results are no longer "ivory tower" materials but are often mass produced for commercialization. The criteria for R&D and market success are much more stringent which require in-depth understanding of the development of the biological sciences and technologies as well as sound business decisions and good management executions. From the biotechnology industry product success point of view, the first success wave is health care, particularly human pharmaceuticals; the second wave is agriculture biotechnology; the third including biological processes to improve the production of chemicals and fuels and clean up industrial toxins and wastes is still offshore. This talk will briefly review the history of biotechnology and concentrate on the current situation of the industry. Topics covered include some statistics (year and region of company founding, biotech/pharmaceutical industry comparable metrics, financial trend analysis, the "Merck/Biotech Index", etc.), defining events of the year (1993-1995), legislation and health care reform, product analysis (top ten biotech drugs), selected biotech company profiles, and emerging R&D and business concerns (virtual integration, and if time permits, prime areas for biotechnology commercialization, critical biotechnology instrumentation systems, hot biotechnology jobs for 1990s, most influential pieces of biotechnology legislation, premier biotechnology research targets, keys to success for a biotechnology company, and critical issues for biotechnology's future).

2.
The Universe of Diagnostic Imaging Agents

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Four major modern diagnostic modalities have emerged to show great promise in terms of their market and future development¡Gmagnetic resonance imaging (MRI), X-ray computed tomography (XRCT), diagnostic ultrasound (DU)¡Aand nuclear medicine/ scintigraphic imaging (SPECT and PET). The total market size including in vitro diagnostic kits and supplies is in excess of 4 billion US dollars worldwide (1988) and is growing rapidly. In each modality, contrast enhancement agents have been developed to improve the accuracy of diagnosis of diseases. These agents, either currently in use or under development, will be discussed in terms of their chemical and biological properties and clinical applications. Major in vivo diagnostic pharmaceutical players such as Schering AG, Hafslund Nycomed, Bristol-Myers Squibb, Sterling Winthrop Sanofi, Mallinckrodt, and Bracco as well as a few emerging biotechnology companies such as Advanced Magnetics and Molecular Biosystems will also be briefly accessed in terms of their product lines and potential future business and R&D directions.

3.
Metal Complexes As Magnetic Resonance Imaging (MRI) Contrast Agents

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Several lanthanide and transition metal complexes of aminocarboxylates are either commercially available, or in clinical trials for use as magnetic resonance imaging (MRI) contrast agents. Unlike the radioactive and X-ray contrast agents, the MRI contrast agents function in an indirect fashion. The MR signal of body fluids can be altered by the presence of paramagnetic water relaxation agents to result in enhanced image contrast. The design, synthesis, and characterization of four gadolinium(III) MRI contrast agents will be reviewed, i.e. gadopentetate dimeglumine (NMG)2[Gd(DTPA)], gadoterate meglumine (NMG)[Gd(DOTA)], gadoteridol [Gd(HP-DO3A)], and gadodiamide [Gd(DTPA-BMA)], where NMG is N-methylglucamine cation. The thermodynamic stability and selectivity, reactivity and kinetics, relaxivity, osmolality, and structural properties will be emphasize as they define the safety and efficacy of these types of in vivo diagnostic magnetopharmaceuticals. Additional discussion will focus on tissue-specific (e.g., liver) imaging agents and anatomical vs. functional imaging.

4.
The Coordination Chemistry of Macrocyclic Lanthanide Complexes

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The study of lanthanide complexation by macrocyclic ligands has recently drawn considerable attention because the results may be useful in application such as the design and development of magnetic resonance imaging (MRI) contrast agents, separation methods, synthetic ionophores, and models of protein metal binding sites. Over the last several years, we have performed equilibrium, kinetic, and structural studies to understand the coordination and physical properties of lanthanide complexes of several aza and mixed aza/oxa macrocyclic ligands with coordinating pendant arms. The results of the aforementioned studies will be reviewed for these ligands and structural properties. Applications to the design of MRI contrast agents and the variation of solvent extraction selectivities (e.g. for nuclear power plant lanthanide waste) will follow.

5.
New Generation Column Packings in Modern Liquid Chromatography

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Over the last twenty years, high performance liquid chromatography (HPLC) has evolved to be one of the most important analytical techniques in many applications such as pharmaceutical, clinical, and environmental analyses. The heart of HPLC is the separation column and the proper choice of suitable column packing material is essential for successful HPLC separation. Many column packing materials have been developed based on silica, alumina, carbon, and polymer supports. The technology and problems of classical as well as new generation column packings will be discussed. Specific examples will be provided concerning the use of cyclodextrin bonded phase columns for geometrical and enantiomeric isomer separations, perfusion chromatography of proteins polynucleotides, DNA and RNA separations, and polymeric, rod-like columns with potential high separation efficiencies.

6.
The Physicoanalytical Chemistry of
Magnetic Resonance Imaging (MRI) Contrast Enhancement Agents

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Case studies of the analytical and physical chemistry of several magnetic resonance imaging contrast enhancement agents, i.e. [Gd(HP-DO3A)] and Na3[Mn(DPDP)], will be discussed. Emphases will be placed on the design principles such as "ligand pre-organization for metal ion complexation" and analytical and bioanalytical method development and validation, true radiotracer labeling, and clinical sample treatment procedure development. To develop appropriate analytical methods and to perform effective trouble shooting, it is important to understand the chemical and biological properties of these metal complexes, their potential reactions which may lead to metabolites, as well as the manufacturing processes of the drug substances and products.

7.
The Market of Radiopharmaceuticals

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The use of radiopharmaceuticals for diagnostic as well as therapeutic purposes is unique and complementary to other "cold" pharmaceuticals. For example, radionuclide imaging techniques such as single-photon emission computed tomography (SPECT) and positron emission tomography (PET) have the sensitivity and specificity that no other imaging modalities can match. In this talk, the market of radiopharmaceuticals will be defined first. Other topics will then follow: industry development history, imaging modalities and therapeutic methods, product overview, market size and major market trend, major technology trend, major competitive factors, pricing trend, industry structure and issues, and strategies for success.

8.
Biotechnology, Pharmaceuticals, and Medical Diagnostic Instrumentation Market Analysis Series

1. Biotechnology Instrumentation and Software Market
2. World Biomedical Sensor Market
3. U.S. Immunodiagnostic Market
4. Competitive Markets for Vitamins and Supplements
5. Biotechnology Food and Nutrition Products Market
6. U.S. Biomedical Materials Market
7. Monoclonal Antibodies Market
8. Molecular Probe Market
9. The U.S. Market for DNA Probes
10. Biopesticide and Biofertilizer Markets
11. Profiles to Success in Biotechnology
12. The U.S. Market for Therapeutic Peptides
13. Agricultural Biotechnology
14. The European Market for Drug Delivery Systems
15. World Gastrointestinal Pharmaceuticals Markets
16. World Antimicrobials Market
17. World Pain Management Markets
18. Respiratory Pharmaceuticals Market
19. Ophthalmic Pharmaceutical Markets
20. Diverse Medications and Products in World Dermatology Markets
21. The U.S. Market for Antihypertensive Agents
22. Diabetes Product Markets
23. Anesthesia Drug Markets
24. The Revitalized World Obstetrics and Gynecological Pharmaceuticals Market
25. New Technologies in the World Neurological and Psychotherapeutic Pharmaceutical Markets
26. Autoimmune Disease Therapeutic Markets
27. Generic Prescription Pharmaceuticals Markets
28. Total World Diagnostic Equipment Market
29. Increasing Demand Typical of U.S. Ethical Nutrition Markets
30. Home Diagnostic and Monitoring Product Markets
31. Endoscopes and Peripheral Equipment Markets

Thesis Supervised (Since 1995)

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1.M.S. Áµo©[F.K. Shieh ¦hÓi»P¦h¤A»Ä°ò°t¦ì¤l»Pª÷ÄÝÂ÷¤l¿ù¦Xª«Ã­©w±`¼Æ¬ã¨sThe Stability Constants Studies of Metal Ion Complexes of Polyamines & Polyamino Polycarboxylates 1996.06
2.M.S. ³¢¥ÃÙyY.B. Kuo ½Þ·½¸ÉÅé³J¥ÕC1qªº¯Â¤Æ¤Î©w©Ê»P©w¶q¤§¬ã¨sThe Purification and Characterization of Complement C1q From Swine 1996.06
3.M.S. ¸U½UL. Wan «ÕªùÁ³±Û±ìµß·P¬V¬°²Õ´²Ó­M©Ò¤Þµo°ò¦]®t²§ªí²{¤§¬ã¨sStudy of the Differential Gene Expression in Human Gastric Cells Infected with Helicobacter pylori 1997.06
4.M.S. ¼ï¬ü»TM.R. Pan ½Þ·½¸ÉÅé³J¥ÕC1q¤§»s³Æ»P¨äÃþpeptideÀ³¥Î¤§¬ã¨sThe Preparation and Applications of Porcine C1q and The C1q-like Peptide 1997.06
5.M.S. §õ«G½nL.W. Lee µ²¸zª½¸zÀù°ò¦]®t§Oªí²{¤§¬ã¨sStudy of Genes Expression in Colorectal Adenocarcinoma by DDRT-PCR Method 1997.06
6.M.S. ³\§e¦wT.A. Hsu ¥Òª¬¸¢¸~½F¼Ð°O¤§¬ã¨sThe Search of Tumor Markers for Thyroid Carcinoma 1998.06
7.M.S. ¾Gª@¨KS.P. Cheng À£¹q´¹Åé§K¬Ì·P´ú¾¹©óÂåÀøÀËÅ礧À³¥ÎThe Application of Piezoelectric Crystal Immunosensor in Clinical Diagnosis 1998.06
8.M.S. Á©ú§»M.H. Shieh ©T©w²Ó­M¥Í²£©M¦^¦¬·»¸²µå²yµß¯À¤§¬ã¨sStudy of the in situ Recovery of Lysostaphin by Immobilized Recombinant Cells 1998.06
9.M.S. ºÞ§G¶³P.Y. Kuan ùS¨tª÷ÄÝ»P¤jÀô°t¦ì¤l¿ù¦Xª«¤Á³ÎÁC»Ä¤Gà­»P¥h®ñ®ÖÁޮֻİʤO¾Ç¤Î¶Ê¤Æ®Ä¤O¤§¬ã¨sKinetic & Catalytic Activity Study of Lanthanide Complex of DO2A & K21DA in Phosphate Diester & DNA Hydrolysis 1998.06
10.M.S. ±i¥Ã¥ßY.L. Chang ¥xÆWÂåÀø»ö¾¹²£·~Àô¹Ò»P¥«³õÄvª§µ¦²¤The Environment of Medical Instrument Industry and Its Competitive Strategies in Taiwan 1998.06
11.M.S. ªL©s¹ÅM.G. Lin ¥H¤j¸z±ìµßªí²{¤HÃþ­L½L«P¨Å¿E¯À¤§¬ã¨sThe Expression of Human Placental Lactogen by E. coli Expression System 1999.06
12.M.S. ³\¦a§QD.L. Hsu ¤j¸zª½¸z¤À¤l¼Ð¼m¤§¬ã¨sStudy of the Bio-molecular Markers in Colorectal Cancers 1999.06
13.M.S. ±i¦ÜªNC.G. Chang «ÕªùÁ³±Û±ìµßÀTÁC¯××Qªº¯Â¤Æ¤Î¨ä¯S©Ê¤§¬ã¨sPurification and Characterization of the Sphingomyelinase of Helicobacter pylori 1999.06
14.M.S. ³¯®a²ÞG.L. Chen ùS¨tª÷ÄÝ»P¤jÀô¦hÓi¦h»Ä°ò°t¦ì¿ù¦Xª«ªº°Ê¤O¾Ç¬ã¨s¤Î¨ä¦bDNA/RNA¤ô¸Ñ¤WªºÀ³¥ÎKinetics Studies of Lanthanide Polyaza Polycarboxylate Macrocyclic Complexes Ln(DO2A) and Their Applications in DNA/RNA Hydrolytic Scission 2000.07
15.M.S. §º°û­sW.C. Song ¥H¤j¸z±ìµßªí²{¤HÃþªí¥Ö¥Íªø¦]¤l±µ¨üÅé-2¤§¬ã¨sExpression of Recombinant Human Epidermal Growth Factor Receptor-2 in E. coli 2000.07
16.Ph.D. ³¯®Û²KK.T. Chen ¥Òª¬¸¢¸~½F¤À¤l¼ÐÁ³±Û±ìµß¤§½¤³J¥Õ¢wµvÁC»Ä»Ã¯À¤§©w©Ê©w¶q¬ã¨sStudies of Potential Protein Markers of Thyroid Carcinoma N/A
17.M.S. ´¿Ä~¾WG.F. Tseng Optimization of the expression of human placental lactogen by E. coli expression system N/A
18.M.S. ù¤d´@C.T. Lo ¦hÁÞ¯uµßµßµ·Å餧¿z¿ï»P°ò¦]¤ñ¹ïPolysarcharide and DNA Ringer Printing of Microorganisms N/A
19.M.S. ºÞ¿PªåY.Y. Kuan µ}¤g°t¦ì¤Æ¦Xª«¤§DNA/RNA ¤Á³Î¾¯Artificial Lanthanide DNA/RNA Nucleases N/A
20.M.S. ¬_­^¼äI.J. Ko The Functional Study of Human Placental Lactogen N/A
21.M.S. ¤ý¤å§»W.H. Wang µ}¤g°t¦ì¤Æ¦Xª«¤§DNA/RNA ¤Á³Î¾¯Artificial Lanthanide DNA/RNA Nucleases N/A
22.Ph.D. ªL§Ó¸ÛC.C. Lin ÂùÅéºÏ®¶³y¼v¾¯Dimeric MRI Contrast Enhancement Agents N/A
23.Ph.D. ÂŨص×P.G. Lan The Functional Study of Human Placental Lactogen N/A
24M.S. §d¬f§»B.H. Wu µ}¤g°t¦ì¤Æ¦Xª«¤§DNA/RNA ¤Á³Î¾¯Artificial Lanthanide DNA/RNA Nucleases