林 苕 吟

Tiao-Yin Lin

Email: tylin@cc.nctu.edu.tw

學歷:

國立台灣大學動物系學士.

美國普渡大學化學系博士.

經歷:

麻省理工學院(M.I.T.), Whitehead Institute of Biomedical Research 研究員 ,   1987-1990.

Brandeis University 研究員, 1990-1994.

交通大學副教授 , 1994-現職.

教學課程:

高等生物化學及分子生物學

高等物理生物化學

普通生物學

普通生物學實驗等

著作:

Leu, G.-Z., Lin, T.-Y., Hsu, J. T.A. 2005. Inhibition of hepatitis virus C replication by arachidonic acid and its peroxidative product. Manuscript in preparation.

Hwang, D.-R., Lin, R.-K., Leu, G.-Z., Lin, T.-Y., Lien, T.-W., Yu, M.-C., Yeh, C.-T., Hsu, J.T. 2005. Inhibition of Hepatitis C Virus Replication by Antimonial Compounds. Antimicrob. Agents Chemother 49, 4197-4202.

Leu, G.-Z., Lin, T.-Y., Hsu, J. T.A. 2004. Anti-HCV activities of selective polyunsaturated fatty acids. Biochem. Biophys. Res. Comm. 318, 275-280.

Lin, T.-Y., & Chen, T.-S. 2004. A positive at position 33 of thioredoxin primarily affects its interactions with other proteins but not redox potential. Biochemistry 43, 945-952.　

Lu, S. M. et al. 2001. Predicting the reactivity of proteins from their sequence alone.  Proc. Natl. Acad. Sci., U.S.A. 98, 1410-1415.

Lin, T.-Y.  1999. G33D mutant thioredoxin primarily affects the kinetics of reaction with thioredoxin reductase. Probing the structure of the mutant protein. Biochemistry 38, 15508-15513.

Pasternak, a., Liu, X., Lin, T.-Y., Hedstrom, L. 1998. Activating a zymogen without proteolytic processing: Mutation of Lys15 and Asn194 Activates Trypsinogen. Biochemistry 37, 16201-16210.

Lin, T.-Y., & Timasheff, S. N. 1996. On the role of surface tension in the stabilization of globular proteins. Protein Science 5, 372-381.

Hedstrom, L., Lin, T.-Y., & Fast, W. 1996. Hydrophobic interaction controls zymongen activation in the trypsin family of serine proteases. Biochemistry 35, 4515-4523.

Kita, Y., Arakawa, T., Lin, T.-Y., & Timasheff, S. N., 1994. Contribution of the surface free energy perturbation to protein-solvent interactions. Biochemistry 33, 15178-15189.

Lin, T.-Y., & Timasheff, S.N., 1994. Why do some organisms use a urea-methylamine mixture as osmolyte? Thermodynamic compensation of urea and methylamine N-oxide interactions with protein. Biochemistry 33, 12695-12701.

Musil, D., Bode, W., Huber, R., Laskowki, M., Jr., Lin, T.-Y., & Ardelt, W. 1991. The refined X-ray crystal structures of the reactive site modified ovomucoid inhibitor third domains form Silver Pheasant (OMSVP3*) and from Japanese Quail (OM JPQ3*). J. Mol. Biol. 220, 739-755.

Lin, T.-Y, & Kim, P. S. 1991. Evaluating the effects of a single amino acid substitution on the native and the denatured states of a protein. Proc. Nat1 Acad. Sci-USA 88:10573-10577.

Lin, T.-Y. & Kim, P. S. 1989. Urea dependence of thiol-disulfide equilibria in thioredoxin: Confirmation of the linkage relationship and a sensitive assay for structure. Biochemistry 28, 5282-5287.

Wang, R., Cotter, R. J., Lin, T.-Y., & Laskowski, M., Jr. 1988. Plasma desorption mass spectrometric analysis of glycosylated ovomucoid third domain from Japanese Quail. Rapid communication in mass spectrometry 2, 71-73.

Lin, T.-Y., Cook, J. A., & Laskowski, M., Jr. 1985. HPLC separation of natural mixtures of ovomucoid third domains differing by a single amino acid substitution. Biochemsitry 24, 3385.

大型會議應邀演講:

“ The Role of Surface Tension in globular Protein Stabilization” in International Symposium on biophysics and structural biology, 1995.

“Measurements of Effective Concentration of Thiols in Proteins” in The Third Symposium on Recent Advances in biophysics, 1997.

 "I do not know what I may appear to the world; but to myself I seem to have been only like a boy playing on the seashore, and diverting myself in now and then finding a smoother pebble or a prettier shell than ordinary, whilst the great ocean of truth lay all undiscovered before me." ~Sir Isaac Newton, English physicist (1642-1727)

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