CURRICULUM VITAE
Yuh-Shyong Yang (楊裕雄)
Education:
1983-1987 Ph.D., Biochemistry, University of Wisconsin-Madison.
1981-1983 M.S., Wood Science&Technology, University of California-Berkely.
1975-1979 B.S., Forestry, National Taiwan University.
Research interest:
1. Mechanisms of enzyme action and protein engineering
2. Bioelectronics and enzyme chip
3. Biochemical ecology
4. Industrial application of enzymes
Experience:
2003- Director, Institute of Biochemical Engineering, College of Biological Science and Technology, National Chiao Tung University
2001-2002 Science and technical consultant, ECHEM Hightech Co. LTD, Hsinchu, Taiwan
1999-2001 Chair, Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan, ROC.
1994- Associate Professor, Institute of Biological Science and Technology,
National Chiao Tung University, Hsinchu, Taiwan, ROC.
1996 Research consultant, Research Lab., Taiwan Salt Works, Tainan, Taiwan, ROC.
1992-1994 Visiting Associate, Laboratory of Biochemistry and Metabolism,
National Institutes of Diabetes and Digestive and Kidney Diseases,
National Institutes of Health, Maryland, USA.
1989-1992 Visiting Fellow, Laboratory of Biochemistry and Metabolism,
National Institutes of Diabetes and Digestive and Kidney Diseases,
National Institutes of Health, Maryland, USA.
1988-1989 Postdoctoral Research Associate, Institute for Enzyme Research,
University of Wisconsin–Madison, Wisconsin, USA.
1987-1988 Guest Jr. Research Associate, Department of Biology, Brookhaven
National Laboratory, Long Island, New York, USA.
1985-1986 Teaching Assistant, Department of Biochemistry, University of
Wisconsin– Madison, Wisconsin, USA.
1983-1987 Research Assistant, Institute for Enzyme Research, University of Wisconsin–Madison, Wisconsin, USA.
1981-1983 Research Assistant, Forest Product Laboratory, University of
California–Berkeley, California, USA.
1979-1981 Project Assistant, Natural Area Reserve, Hen-chun Tropical Botanical
Garden, Henchun, Taiwan.
Publications:
1. 徐國士,劉培槐,張惠珠,呂勝由,楊遠波,楊裕雄,陳學仁,劉玉水, “臺灣稀有及有絕滅危機之植物”, 科學教育資料叢書, 臺灣省政府教育廳, 1980
2. Yang, Y.-S. and Frey, P.A. (1986) Dihydrolipoyl Transacetylase of Escherichia coli. The Formation of 8-S-Acetyldihydrolipoamide, Biochemistry 25, 8173-8178.
3. Yang, Y.-S. and Frey, P.A. (1989) 2-Keto acid Dehydrogenase Complexes of Escherichia coli. Stereospecifity of the three components for (R)-lipoic acid, Ach. Biochem. Biophys. 286, 465-474.
4. Frey, P.A., Flournoy, D., Gruys, K. and Yang, Y.-S. (1989) Intermediates in Reductive Transacetylation Catalyzed by Pyruvate Dehydrogenase Complex, Annals of the New York Academy of Sciences, 573, 21-359.
5. Kim, D.-H., Yang, Y.-S. and Jakoby, W.B. (1990) Aspirin Hydrolyzing Esterases from at Liver Cytosol, Biochemical Phamarcology 40, 481-487.
6. Kim, D.-H., Yang, Y.-S. and Jakoby, W.B. (1990) Non-Serine Esterases from Rat Liver Cytosol, Protein Expression and Purification 1, 19-27.
7. Yang, Y.-S. and Frey, P.A. (1990) Solvent Effects on the Solvolysis of ADP�浿, Bioorganic Chemistry 18, 373-380.
8. Chen, X., Yang, Y.-S., Zheng, Y., Martin, B., Duffel, M., and Jakoby, W.B. (1992) Tyrosine-Ester Sulfotransferase from Rat Liver: Bacterial Expression and Identification, Protein Expression and Purification 3, 421-426.
9. Yang, Y.-S., Ramaswamy, S., and Jakoby, W.B. (1993) Rat Liver Imidase, The Journal of Biological Chemistry 268, 10870-10875.
10. Guo, W.-X., Yang, Y.-S., Chen, X., McPhie, P., and Jakoby, W.B. (1994) Changes In Substrate Specificity in the Recombinant Form of Phenol Sulfotransferase IV. Chemico-Biological Interactions 92, 25-31.
11. Yang, Y.-S., Datta, A. Funiya, F.R., Hainfeld, J.F. Hainfeld, Wall, J.S., and Frey, P.A. (1994) Mapping the Lipoyl Groups of the Pyruvate Dehydrogenase Complex by the Use of Undecagold Clusters and Scanning Transmission Electron Microscopy, Biochemistry 33, 9428-9437.
12. 楊裕雄, 吳若薇, “疫苗農場 - 談可食疫苗及其它”, 農訊月刊, 第12卷, 第7期, 93-94頁, 1995.
13. Yang, Y.-S., Marshall, A.D., McPhie, P., Guo, W.-X., Xie, X., Chen, X., and W.B. Jakoby (1996) Two Phenol Sulfotransferase Species from One cDNA: Nature of the Differences Protein Expression and Purification, 8, 423-429.
14. 吳若薇, 楊裕雄, “基因農產品進駐美國超市”,農訊月刊,第13卷, 第1期, 93-94頁, 1996.
15. 楊裕雄, 吳若薇, “溫室效應外ㄧ章：大氣中二氧化炭濃度升高對農作物是否有影響？”, 農訊月刊, 第13卷, 第9期, 73-74頁, 1996.
16. Yang, Y.-S., Pan, J.-J. and Hwang, J.-K. (1997) Probing Phenol Binding Environment of Sulfotransferase, Protein Engineering 10, 70 Suppl. S.
17. 吳若薇, 楊裕雄, “最古老與最尖端的行業 - 農業生物技術”, 農訊月刊農訊月刊, 第14卷, 第5期, 10-15頁, 1997.
18. 楊裕雄, “生物科技：談基因工程與蛋白質工程”, 交大世紀之慶學術研討會文集, 195-207頁, 1997.
19. Yang, Y.-S., Tsai, S.-W. and Lin, E.-S. (1998) Effect of 3’-Phospho Adenosine 5’-Phosphate on the Activity of Sulfotransferase. Chemico-Biological Interactions, 109, 129-135.
20. Lin, E.-S. and Yang, Y.-S. (1998) Colormetric Determination of the Purity of 3’-Phospho Adenosine 5’-Phosphosulfate and Natural Abundance of 3’Phosspho Adenosine 5’-Phosphate at picomole Quantities. Analytical Biochemistry, 262, 111-117.
21. 袁俊傑, 楊裕雄, “酵素晶片”, 科學月刊, 第33卷, 第9期, 733-738頁, 1999.
22. Su, T.-M. and Yang, Y.-S. (2000) Identification and Purification of a Thermophilic Imidase from Pig Liver, Protein Expression and Purification, 19, 289-297.
23. Lin, E.-S. and Yang, Y.-S. (2000) Nucleotide Binding and Sulfation Catalyzed by Phenol Sulfotransferase, Biochem. Biophys. Res. Comm., 271, 818-822.
24. Yang, Y.-S., Lu, U. and. Hu, B.C.P (2002) Prescription Chips: Toward the Development of Enzyme and Biochemical CMOS Chips, IEEE Circuits & Devices, 18, 8-16.
25. Huang, C.-Y. and Yang, Y.-S. (2002) The Role of Metal on Imide Hydrolysis: Metal Content and pH Profiles of Metal Ion Replaced Mammalian Imidase, Biochem. Biophys. Res. Comm., 297, 1027-1032.
26. Hsiao, Y.-S. and Yang, Y.-S. (2002) A Single Mutation Converts the Nucleotide Specificity of Phenol Sulfotransfrese from PAP to AMP, Biochemistry, 41, 12959-12966.
27. Yang, Y.-S. (2002) The Development of Enzyme and Biochemical Chip:From Bioelectronics to Nanobioelectronics, Proceedings of APAM 2002 International Conference on International Collaboration and Networking:Creating a Global Nanotechnology Network, 32-33.
28. 楊裕雄, 李奇翰, “生命科學跨領域整合性網路教材設計與製作”, ELTA 2002, Workshop on E-Learning Theory & Applications, 125-130頁, 2002.
29. Lee, C., Lin, Y.-T., *Tang, C.-Y. and *Yang, Y.-S. (2003) Identify Amino Acid Candidates Critical for Structure/Function of Rat Imidase by Cross-Reference Voting in Imidase Super Family, 18th ACM SAC track on Bioinformatics, SAC 2003: 127-134.
30. 楊裕雄, “奈米生物電子系統: 從生物微電子到奈米生物電子”, 奈米世界-賦予大學新機會, 吳重雨 編著, 高力圖書出版公司, 146-170頁, 2003.
31. Lu, U, Hu, B.C.P, Shih, Y.-C., *Yang, Y.-S., Wu, C.-Y., Yuan, C.-J., Ker, M.-D., Wu, T.-K., Li, Y.-K., Hsieh, Y.-Z., Hsu, W., and Lin, C.-T. (2003) CMOS Chip As Luminescent Sensor For Biochemical Reactions, IEEE Sensors Journal, 3, 310-316.
32. Huang, C.-Y., Chiang, S.-K., *Sun, Y.-J., and *Yang, Y.-S. (2003) Crystallization and Preliminary X-ray Diffraction Analysis of Thermophilic Imidase from Pig Liver. Acta Cryst. D., 59, 943-945.
33. Huang, C.-Y., Chao, Y.-P. and *Yang, Y.-S. (2003), Purification of Industtrial Hydantoinase in One Chromatographic Step without Affinity Tag, Protein Expression and Purificaiton, 30, 134-139.
34. Su, T.-M. and *Yang, Y.-S. (2003) Mechanism of Post Translational Regulation of Phenol Sulfotransferase: Expression of Two Enzyme Forms through Redox Modification and Nucleotide Binding, Biochemistry, 42, 6863-6870.
35. Lin, E.-S., Yang, J.-M. and *Yang, Y.-S. (2003) Modeling the Binding and Inhibition Mechanism of Nucleotide and Sulfotransferase Using Molecular Docking, J Chinese Chemical Soc, 50, 655-663.
36. Sugahara, T.,Yang, Y.-S., Liu, C.-C. Pai, G. T. Liu, M.-C. (2003) Sulphonation of Dehydroepiandrosterone and Neurosteroids: Molecular cloning, expression, and functional characterization of a novel Zebrafish SULT 2Cytosolic Sulphotransferase Biochem. J., in press
37. Lu, U., Hu, B. C.-P., Shih, Y.-C., Wu, C.-Y., Yang, Y.-S. (2003) The Design of a Novel CMOS Detection System for Biochemical Luminescence, Biosensors and Bioelectronics, accepted